Total parenteral nutrition containing medium- vs. long-chain triglyceride emulsions elevates plasma cholesterol concentrations in rats.

Ney, DM ; Yang, H ; et al.

In: The Journal of nutrition, Jg. 123 (1993-05-01), Heft 5, S. 883-92

academicJournal

Male Fischer 344 rats (235-246 g) were fed for 6-14 d by intravenous or intragastric infusion with total parenteral nutrition (TPN) solutions providing 40 or 65% of nonprotein energy as fat from long-chain triglyceride (LCT) or a 3:1 admixture of medium-chain triglyceride (MCT) and LCT emulsions. In three separate experiments, plasma cholesterol concentrations were significantly greater (24-32%) with intravenous infusion of TPN solutions containing MCT-LCT rather than LCT. Plasma cholesterol concentrations in rats were not significantly different with intragastric infusion of TPN solutions containing MCT-LCT rather than LCT. Hepatic total lipid and triglyceride concentrations were not significantly different. Hepatic total cholesterol and esterified cholesterol concentrations were significantly lower in animals given 65% of energy from MCT-LCT rather than LCT emulsions (main effects, two-way ANOVA). The concentration of individual hepatic acyl-CoA esters reflected the fatty acid profiles of the lipid emulsions infused. Total hepatic acyl-CoA concentrations suggested differences in utilization of acyl-CoA esters with intravenous infusion of MCT-LCT rather than LCT and were consistent with rapid oxidation of MCT. These data demonstrate that MCT-LCT elevates plasma cholesterol concentrations compared with LCT emulsions with intravenous, but not with intragastric, infusion of TPN solutions in rats.

Titel:	Total parenteral nutrition containing medium- vs. long-chain triglyceride emulsions elevates plasma cholesterol concentrations in rats.
Autor/in / Beteiligte Person:	Ney, DM ; Yang, H ; Rivera, J ; Lasekan, JB
Zeitschrift:	The Journal of nutrition, Jg. 123 (1993-05-01), Heft 5, S. 883-92
Veröffentlichung:	2023- : [New York, NY] : Elsevier ; <i>Original Publication</i>: 1928-1933 : Springfield, Ill. : C. C. Thomas, 1993
Medientyp:	academicJournal
ISSN:	0022-3166 (print)
DOI:	10.1093/jn/123.5.883
Schlagwort:	3-Hydroxybutyric Acid Acyl Coenzyme A drug effects Acyl Coenzyme A metabolism Animals Body Weight drug effects Cholesterol blood Emulsions Fat Emulsions, Intravenous pharmacology Hydroxybutyrates blood Infusions, Parenteral Liver drug effects Liver metabolism Male Organ Size drug effects Rats Rats, Inbred F344 Triglycerides administration & dosage Cholesterol metabolism Parenteral Nutrition, Total Triglycerides pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Language: English [J Nutr] 1993 May; Vol. 123 (5), pp. 883-92. MeSH Terms: Parenteral Nutrition, Total* ; Cholesterol / metabolism ; Triglycerides / pharmacology ; 3-Hydroxybutyric Acid ; Acyl Coenzyme A / drug effects ; Acyl Coenzyme A / metabolism ; Animals ; Body Weight / drug effects ; Cholesterol / blood ; Emulsions ; Fat Emulsions, Intravenous / pharmacology ; Hydroxybutyrates / blood ; Infusions, Parenteral ; Liver / drug effects ; Liver / metabolism ; Male ; Organ Size / drug effects ; Rats ; Rats, Inbred F344 ; Triglycerides / administration & dosage Grant Information: R29 DK42835-02 United States DK NIDDK NIH HHS Substance Nomenclature: 0 (Acyl Coenzyme A) ; 0 (Emulsions) ; 0 (Fat Emulsions, Intravenous) ; 0 (Hydroxybutyrates) ; 0 (Triglycerides) ; 97C5T2UQ7J (Cholesterol) ; TZP1275679 (3-Hydroxybutyric Acid) Entry Date(s): Date Created: 19930501 Date Completed: 19930607 Latest Revision: 20180330 Update Code: 20240513

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