Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b.
In: Immunity, Jg. 6 (1997-06-01), Heft 6, S. 739-49
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Zugriff:
Fas/APO-1(CD95) ligation activates programmed cell death, a cellular process that plays an important role in the maturation of the host immune response. We show that activation of a specific MAP kinase kinase (MKK), MKK6b, is necessary and sufficient for Fas-induced apoptosis of Jurkat T cells. MKK6b activation occurs downstream of an interleukin-1 converting enzyme-like (ICE-like) protease(s), while execution of the apoptotic pathway by MKK6b requires both ICE- and CPP32-like proteases. Surprisingly, the p38 MAP kinase protein, a known substrate of MKK6b, does not participate in Fas/MKK6b-mediated apoptosis. These findings indicate a divergence of the MKK6b signaling pathways, one of which activates p38 and leads to regulation of gene expression, and one of which activates the ICE/Ced-3 family of proteases and leads to cell death. These studies represent a demonstration of an apoptotic pathway that is comprised of both the ICE/Ced-3 family of proteases and MAP kinase kinase 6.
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Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b.
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Autor/in / Beteiligte Person: | Huang, S ; Jiang, Y ; Li, Z ; Nishida, E ; Mathias, P ; Lin, S ; Ulevitch, RJ ; Nemerow, GR ; Han, J |
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Zeitschrift: | Immunity, Jg. 6 (1997-06-01), Heft 6, S. 739-49 |
Veröffentlichung: | Cambridge, MA : Cell Press ; <i>Original Publication</i>: Cambridge, Mass. : Cell Press, c1994-, 1997 |
Medientyp: | academicJournal |
ISSN: | 1074-7613 (print) |
DOI: | 10.1016/s1074-7613(00)80449-5 |
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