Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I.

Hiraki, Y ; Kono, T ; et al.

In: FEBS letters, Jg. 415 (1997-10-06), Heft 3, S. 321-4

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Cartilage is an avascular tissue, and exhibits anti-angiogenic properties. Cartilage extracts have been shown to contain an inhibitor for DNA synthesis in vascular endothelial cells in vitro. Here we purified the inhibitory activity in the 10-50 kDa fraction of guanidine extracts from fetal bovine epiphyseal cartilage, and found that the inhibitor was identical with chondromodulin-I (ChM-I). Purified ChM-I inhibited tube morphogenesis of cultured vascular endothelial cells, as well as DNA synthesis. These results indicate that cartilage-specific glycoprotein ChM-I may participate in the maintenance of avascularity and anti-angiogenic properties of cartilage.

Titel:	Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I.
Autor/in / Beteiligte Person:	Hiraki, Y ; Kono, T ; Sato, M ; Shukunami, C ; Kondo, J
Link:	Full Text Finder (Volltext) E-Journal im Bestand der UB Hagen?
Zeitschrift:	FEBS letters, Jg. 415 (1997-10-06), Heft 3, S. 321-4
Veröffentlichung:	Jan. 2016- : West Sussex : John Wiley & Sons Ltd. ; <i>Original Publication</i>: Amsterdam, North-Holland on behalf of the Federation of European Biochemical Societies., 1997
Medientyp:	academicJournal
ISSN:	0014-5793 (print)
DOI:	10.1016/s0014-5793(97)01151-4
Schlagwort:	Animals Carotid Arteries cytology Cattle Cell Size drug effects Cells, Cultured Chromatography, Affinity Chromatography, Gel Dose-Response Relationship, Drug Endothelium, Vascular cytology Glycoproteins metabolism Growth Substances isolation & purification Growth Substances metabolism Morphogenesis drug effects Neovascularization, Physiologic drug effects Nucleic Acid Synthesis Inhibitors chemistry Nucleic Acid Synthesis Inhibitors isolation & purification Thymidine metabolism DNA biosynthesis Endothelium, Vascular drug effects Growth Plate chemistry Growth Substances pharmacology Intercellular Signaling Peptides and Proteins Nucleic Acid Synthesis Inhibitors pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [FEBS Lett] 1997 Oct 06; Vol. 415 (3), pp. 321-4. MeSH Terms: Intercellular Signaling Peptides and Proteins* ; DNA / biosynthesis ; Endothelium, Vascular / drug effects ; Growth Plate / chemistry ; Growth Substances / pharmacology ; Nucleic Acid Synthesis Inhibitors / *pharmacology ; Animals ; Carotid Arteries / cytology ; Cattle ; Cell Size / drug effects ; Cells, Cultured ; Chromatography, Affinity ; Chromatography, Gel ; Dose-Response Relationship, Drug ; Endothelium, Vascular / cytology ; Glycoproteins / metabolism ; Growth Substances / isolation & purification ; Growth Substances / metabolism ; Morphogenesis / drug effects ; Neovascularization, Physiologic / drug effects ; Nucleic Acid Synthesis Inhibitors / chemistry ; Nucleic Acid Synthesis Inhibitors / isolation & purification ; Thymidine / metabolism Substance Nomenclature: 0 (Glycoproteins) ; 0 (Growth Substances) ; 0 (Intercellular Signaling Peptides and Proteins) ; 0 (Nucleic Acid Synthesis Inhibitors) ; 9007-49-2 (DNA) ; VC2W18DGKR (Thymidine) Entry Date(s): Date Created: 19971114 Date Completed: 19971125 Latest Revision: 20190621 Update Code: 20240513

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