[Biochemical parameters in the diagnosis of nephrotoxicity of antineoplastic chemotherapy in children].
In: Voprosy onkologii, Jg. 43 (1997), Heft 4, S. 448-53
academicJournal
Zugriff:
The investigation was concerned with the role of enzymouria in the assessment of nephrotoxic effects identified in 19 children with malignant solid tumors who received cisplatin polychemotherapy in a dose of 100 mg/sq.m or iphosphamide in a dose 9 g/sq.m. Chemotherapy application was followed by a persistent hyperenzymouria involving significantly higher levels of N-acetyl-beta-D-hexosaminidase, beta-glutamyl transferase and alanine aminopeptidase in the urine, as compared with basal indices. Iphosphamide treatment showed significantly higher levels of enzymouria than those in cisplatin-treated patients. Higher than normal creatinine and urea concentrations were recorded only in 2 out of 9 patients receiving iphosphamide. Enzymouria evaluation was shown to be an effective method of nephrotoxic diagnosis.
Titel: |
[Biochemical parameters in the diagnosis of nephrotoxicity of antineoplastic chemotherapy in children].
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Autor/in / Beteiligte Person: | Liubimova, NV ; ZhKh, Kumykova ; Kushlinskiĭ, NE ; ChM, Kasumov ; Durnov, LA |
Zeitschrift: | Voprosy onkologii, Jg. 43 (1997), Heft 4, S. 448-53 |
Veröffentlichung: | 2013-: St Petersburg : Nauchno-issledovatelʹskiĭ institut onkologii im. N.N. Petrova ; <i>Original Publication</i>: St Petersburg : Izdatelstvo Meditsina, Leningradskoe Otdelenie, 1997 |
Medientyp: | academicJournal |
ISSN: | 0507-3758 (print) |
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