Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12.
In: Journal of leukocyte biology, Jg. 64 (1998-09-01), Heft 3, S. 384-92
Online
academicJournal
Zugriff:
The mechanisms by which interleukin-12 (IL-12) exerts antitumor effects have been difficult to dissect. In this study, we examined the potential contribution of the chemokines interferon-gamma-inducible protein-10 (IP-10) and Mig to the antitumor effects of IL-12. Using an athymic mouse model, local inoculations with IL-12 consistently produced tumor size reductions associated with characteristic tumor necrosis and vascular damage. These effects were indistinguishable from those produced by IP-10 or Mig injected locally in the same tumor model. Local and systemic treatment with IL-12 was associated with expression of the interferon-gamma (IFN-gamma), IP-10, and Mig genes and proteins in the tumor. Levels of IP-10 and Mig expression in the tumor, the liver, and the kidney were inversely correlated with tumor size. Administration in vivo of neutralizing antibodies to IP-10 and Mig reduced substantially the antitumor effects of IL-12 inoculated locally into the tumors. These results support the notion that IP-10 and Mig contribute to the antitumor effects of IL-12 through their inhibitory effects on tumor vasculature.
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Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12.
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Autor/in / Beteiligte Person: | Kanegane, C ; Sgadari, C ; Kanegane, H ; Teruya-Feldstein, J ; Yao, L ; Gupta, G ; Farber, JM ; Liao, F ; Liu, L ; Tosato, G |
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Zeitschrift: | Journal of leukocyte biology, Jg. 64 (1998-09-01), Heft 3, S. 384-92 |
Veröffentlichung: | 2023- : Oxford : Oxford University Press ; <i>Original Publication</i>: New York : Alan R. Liss, c1984-, 1998 |
Medientyp: | academicJournal |
ISSN: | 0741-5400 (print) |
DOI: | 10.1002/jlb.64.3.384 |
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