Gas exchange and pulmonary haemodynamic responses to fat emulsions in acute respiratory distress syndrome.
In: Intensive care medicine, Jg. 24 (1998-09-01), Heft 9, S. 918-23
Online
academicJournal
Zugriff:
Objective: To investigate the gas exchange and pulmonary haemodynamic responses to two different intravenous fat emulsions in patients with acute respiratory distress syndrome (ARDS).
Design: Prospective, randomized, double-blind, placebo-controlled study.
Setting: Intensive care unit in a university-affiliated hospital.
Patients: 21 patients with ARDS [mean age, 57 +/- 3 (SEM) years; Acute Physiology and Chronic Health Evaluation II, 20 +/- 3; Murray's score, 2.85 +/- 0.12] consecutively admitted.
Interventions: Patients were assigned to three groups (n = 7 each): group A (LCT) received long-chain triglycerides (20% LCT), group B (MCT/LCT), medium-chain triglycerides/long-chain triglycerides (20% MCT/LCT: 50/50) and group C placebo (0.9% sodium chloride, NaCl). The infusion was always given at the rate of 2 mg/kg min over a total period of 12 h, with a volume infusion of 500 ml in each group.
Measurements: Data were collected before, immediately after and 12 h after infusion ceased. Pulmonary and systemic haemodynamic and gas exchange variables were measured at each time point. Serum triglyceride cholesterol, and non-esterified fatty acids levels were measured.
Results: During LCT infusion, cardiac output, oxygen consumption and oxygen delivery increased (all p < 0.05), whereas pulmonary haemodynamics, arterial oxygen tension, mixed venous partial pressure of oxygen and venous admixture ratio remained essentially unaltered. No changes were observed following MCT/LCT infusion.
Conclusions: The administration of LCT emulsion given at a slow rate did not alter arterial oxygenation because of the beneficial effect of a high cardiac output, hence offsetting the detrimental effect of increased O2 consumption.
| Titel: |
Gas exchange and pulmonary haemodynamic responses to fat emulsions in acute respiratory distress syndrome.
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| Autor/in / Beteiligte Person: | Masclans, JR ; Iglesia, R ; Bermejo, B ; Picó, M ; Rodriguez-Roisin, R ; Planas, M |
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| Zeitschrift: | Intensive care medicine, Jg. 24 (1998-09-01), Heft 9, S. 918-23 |
| Veröffentlichung: | New York : Springer Verlag ; <i>Original Publication</i>: Berlin ; New York, Springer International., 1998 |
| Medientyp: | academicJournal |
| ISSN: | 0342-4642 (print) |
| DOI: | 10.1007/s001340050690 |
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