MR image analysis for the investigation of myocardial contractility
2019
Hochschulschrift
Zugriff:
The aim of this work is to provide novel methods, tools and the theoretical background of an image analysis framework for the generation of consistent and detailed myocardial contractility maps, which have the potential to contribute to an early and accurate diagnosis and prognosis of cardiac disease. The image analysis framework is tailored to Tissue Velocity Mapping (TVM) images. 3D deformation measures from the field of tissue mechanics are examined and their consistency in myocardial studies is investigated; an original theoretical analysis of different strain formulas reveals significant discrepancies. A novel framework for the improvement of consistency in LV segmental contractility analysis is introduced and new interactive tools for the accurate detection of the LV anatomical landmarks and delineation of the myocardium are developed as part of it. A new automatic method for the correction of myocardial segmentation is proposed and improves further the consistency of the segmental maps. Plots of segmental maps are suggested for the intuitive clinical intra- and inter-subject assessment, and the segmental velocity patterns over TVM datasets lead to the newly introduced concept of motion symmetry. A new total-variation based restoration method is introduced which alleviates TVM image noise while preserving the underlying complex and possibly discontinuous myocardial motion; the proposed method improves considerably the consistency of the regional velocity maps, it is robust and less computationally expensive than its homologous methods. Deformational velocity maps are proposed as an alternative to the currently established strain maps for the assessment of contractility. A novel, analytical and fast method for the computation of translational motion is proposed considering two models of left-ventricular symmetry and shows high efficiency on synthetic and in vivo data. The rigid body motion is computed and subtracted from the TVM measurements; the velocity residuals constitute the suggested deformational velocity maps.
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MR image analysis for the investigation of myocardial contractility
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Autor/in / Beteiligte Person: | Koutsoumpa, Christina |
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Veröffentlichung: | 2019 |
Medientyp: | Hochschulschrift |
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