Median-lower normal levels of serum thyroxine are associated with low triiodothyronine levels and body temperature in patients with central hypothyroidism.
In: European Journal of Endocrinology, Jg. 173 (2015-08-01), Heft 2, S. 247-256
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Zugriff:
Objective: Although it has been recommended that serum free thyroxine (FT 4 ) levels should be targeted to middle-upper normal levels during levothyroxine (L-T 4 ) replacement therapy in patients with central hypothyroidism (CeH), the rationale has not been clarified. Methods: A retrospective single-center study enrolled 116 patients with hypothyroidism (CeH, n = 32; total thyroidectomy (Tx), n = 22; primary hypothyroidism (PH), n = 33; and control benign thyroid nodule (C), n = 29). The patients had received L-T 4 therapy at the Kobe University Hospital between 2003 and 2013. They were stratified according to serum FT 4 level (>1.10 or <1.10 ng/dl), and body temperature (BT), serum free triiodothyronine (FT 3 ) levels, FT 3 /FT 4 ratio, and lipid profiles were compared. The effect of GH replacement therapy on thyroid function was also analyzed. Results: FT 3 levels and FT 3 /FT 4 ratios were significantly lower in patients with CeH than in patients with PH (P<0.05) or C (P<0.05). In patients with FT 4 <1.10 ng/dl, BT was significantly lower in patients with CeH (P=0.002) and Tx (P=0.005) than in patients with PH, whereas no differences were found in patients with FT 4 >1.10 ng/dl. In patients with CeH, FT 3 levels were higher in those with GH replacement therapy (P=0.018). Conclusion: In CeH, patients with median-lower normal levels of serum FT 4 exhibited lower serum FT 3 levels and lower BT. These results support the target levels of serum FT 4 as middle-upper normal levels during L-T 4 replacement therapy in patients with CeH. [ABSTRACT FROM AUTHOR]
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Median-lower normal levels of serum thyroxine are associated with low triiodothyronine levels and body temperature in patients with central hypothyroidism.
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Autor/in / Beteiligte Person: | Hirata, Yu ; Fukuoka, Hidenori ; Iguchi, Genzo ; Iwahashi, Yasuyuki ; Fujita, Yasunori ; Hari, Yusuke ; Iga, Makiko ; Nakajima, Shinsuke ; Nishimoto, Yuki ; Mukai, Miki ; Hirota, Yushi ; Sakaguchi, Kazuhiko ; Ogawa, Wataru ; Takahashi, Yutaka |
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Zeitschrift: | European Journal of Endocrinology, Jg. 173 (2015-08-01), Heft 2, S. 247-256 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 0804-4643 (print) |
DOI: | 10.1530/EJE-15-0130 |
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