Randomized controlled trial of an adjuvanted human papillomavirus (HPV) type 6 L2E7 vaccine: infection of external anogenital warts with multiple HPV types and failure of therapeutic vaccination.
In: Journal of Infectious Diseases, Jg. 192 (2005-12-15), Heft 12, S. 2099-2107
Online
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Zugriff:
BACKGROUND: Cellular immunity is involved in spontaneous clearance of anogenital warts caused, most typically, by human papillomavirus (HPV) type 6 or 11, supporting the concept of therapeutic vaccination. A therapeutic vaccine composed of HPV-6 L2E7 fusion protein and AS02A adjuvant was evaluated in conjunction with conventional therapies in subjects with anogenital warts. METHODS: A total of 457 subjects with anogenital warts were screened, of which 320 with HPV-6 and/or HPV-11 infection were enrolled into 2 double-blind, placebo-controlled substudies. Three doses of vaccine or placebo were administered along with either ablative therapy or podophyllotoxin. RESULTS: Although a positive trend toward clearance was seen in patients infected with only HPV-6, in neither substudy did the vaccine significantly increase the efficacy of conventional therapies, despite induction of adequate immune responses. Extensive HPV typing by polymerase chain reaction demonstrated that a majority of screened subjects (73.7%) were infected with HPV-6 and/or HPV-11 and that a large proportion (40.1%) were infected with multiple HPV types. HPV types that put subjects at high risk of development of cervical cancer were detected in 39.8% of subjects. CONCLUSIONS: Infection with multiple HPV types, including high-risk types, is common in anogenital wart disease. Therapeutic vaccination failed to increase the efficacy of conventional therapies. Copyright © 2005 Infectious Diseases Society of America [ABSTRACT FROM AUTHOR]
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Titel: |
Randomized controlled trial of an adjuvanted human papillomavirus (HPV) type 6 L2E7 vaccine: infection of external anogenital warts with multiple HPV types and failure of therapeutic vaccination.
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Autor/in / Beteiligte Person: | Vandepapelière, P ; Barrasso, R ; Meijer, CJL ; Walboomers, JMM ; Wettendorff, M ; Stanberry, LR ; Lacey, CJN |
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Zeitschrift: | Journal of Infectious Diseases, Jg. 192 (2005-12-15), Heft 12, S. 2099-2107 |
Veröffentlichung: | 2005 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1086/498164 |
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