Nine Years of Experience of Systematic Screening of Organ Donors from the Paris Area for Markers of Viral Infection.
In: Transfusion, Jg. 41 (2001-09-02), S. 98S
Online
academicJournal
Zugriff:
Background: Prevention of viral transmission in grafts is based on clinical and biological selection of organ donors. Clinical selection, involving any history of intravenous drug use, of multiple sexual partners, of symptoms of viral infections, has limitations and selection based on detection of markers of viral infection is essential. In France, the following markers are systematically sought in organ donors: anti-human immunodeficiency virus (HIV) antibodies and p24 antigen, anti human T-cell leukemia virus antibodies (HTLV-I), Hepatitis B surface (HBs) antigen, anti-HBs antibodies, anti-HBc antibodies, anti-hepatitis C virus (HCV) antibodies, anti-cytomegalovirus (CMV) antibodies and anti-Epstein-Barr virus (EBV) antibodies. Our unit performs serological testing in organ donors from the Paris area. Study design : we are reporting our experience of systematic testing of potential organ donors from May 1992 to May 2001; 2316 serum samples were tested for previous markers of viral infection using available assays. All samples were tested for HCV and HIV antibody by use of latest generation assays. Results: the prevalence of markers of viral infection over time was steady: anti-HIV antibodies: 1-2%; p24 antigen +/anti-HIV antibodies-: 0%; HBs antigen: 1.52%; anti-HBc antibodies: 12-15%; anti-HCV antibodies: 3.5-5%. Thus, the prevalence of HIV and HCV infection is five and four times higher in organ donors than in the general population in France (0.2% and 1%, respectively). Conclusion: These results suggest that organ donors are at high risk of HIV and/or hepatitis virus infection, which exposes organ recipients to the risk of viral transmission by graft. [ABSTRACT FROM AUTHOR]
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Titel: |
Nine Years of Experience of Systematic Screening of Organ Donors from the Paris Area for Markers of Viral Infection.
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Autor/in / Beteiligte Person: | Challine, D. ; Pawlotsky, J. ; Lefrere, J. |
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Zeitschrift: | Transfusion, Jg. 41 (2001-09-02), S. 98S |
Veröffentlichung: | 2001 |
Medientyp: | academicJournal |
ISSN: | 0041-1132 (print) |
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