Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers.
In: American Journal of Nephrology, Jg. 42 (2016-02-01), Heft 6, S. 436-442
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Zugriff:
Background: Serum creatinine (SCr) levels are decreased following traumatic amputation, leading to the overestimation of glomerular filtration rate (GFR). β-Trace protein (BTP) and β2-microglobulin (B2M) strongly correlate with measured GFR and have not been studied following amputation. We hypothesized that BTP and B2M would be unaffected by traumatic amputation. Methods: We used the Department of Defense Serum Repository to compare pre- and post-traumatic amputation serum BTP and B2M levels in 33 male soldiers, via the N Latex BTP and B2M nephelometric assays (Siemens Diagnostics, Tarrytown, N.Y., USA). Osterkamp estimation using DEXA scan measurements was used to establish percent estimated body weight loss (%EBWL). Results were analyzed for small (3-5.9% EBWL), medium (6-13.5%), and large (>13.5%) amputation subgroups; and for a control group matched 1:1 to the 12 large amputation subjects. Paired Student's t test was used for comparisons. Results: Mean serum BTP levels were unchanged in controls, all amputees, and the small and medium amputation subgroups. BTP appeared to decrease following large %EBWL amputation (p = 0.05). Mean serum B2M levels were unchanged in controls, all amputees, and the small and medium amputation subgroups. B2M appeared to increase following large %EBWL amputation (p = 0.05). Conclusions: BTP and B2M levels are less affected than SCr by amputation, and should be considered for future study of GFR estimation. BTP and B2M changes following large %EBWL amputation require validation and may offer insight into non-GFR BTP and B2M determinants as well as increased cardiovascular disease and mortality following amputation. [ABSTRACT FROM AUTHOR]
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Titel: |
Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers.
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Autor/in / Beteiligte Person: | Little, Dustin J. ; Yuan, Christina M. ; Thurlow, John S. ; Gounden, Verena ; Doi, Sonia Q. ; Pruziner, alison ; abbott, Kevin C. ; Theeler, Brett J. ; Olson, Stephen W. |
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Zeitschrift: | American Journal of Nephrology, Jg. 42 (2016-02-01), Heft 6, S. 436-442 |
Veröffentlichung: | 2016 |
Medientyp: | academicJournal |
ISSN: | 0250-8095 (print) |
DOI: | 10.1159/000443775 |
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