Non-neurogenic SVZ-like niche in dolphins, mammals devoid of olfaction.
In: Brain Structure & Function, Jg. 222 (2017-08-01), Heft 6, S. 2625-2639
Online
academicJournal
Zugriff:
Adult neurogenesis has been implicated in brain plasticity and brain repair. In mammals, it is mostly restricted to specific brain regions and specific physiological functions. The function and evolutionary history of mammalian adult neurogenesis has been elusive so far. The largest neurogenic site in mammals (subventricular zone, SVZ) generates neurons destined to populate the olfactory bulb. The SVZ neurogenic activity appears to be related to the dependence of the species on olfaction since it occurs at high rates throughout life in animals strongly dependent on this function for their survival. Indeed, it dramatically decreases in humans, who do not depend so much on it. This study investigates whether the SVZ neurogenic site exists in mammals devoid of olfaction and olfactory brain structures, such as dolphins. Our results demonstate that a small SVZ-like region persists in these aquatic mammals. However, this region seems to have lost its neurogenic capabilities since neonatal stages. In addition, instead of the typical newly generated neuroblasts, some mature neurons were observed in the dolphin SVZ. Since cetaceans evolved from terrestrial ancestors, non-neurogenic SVZ may indicate extinction of adult neurogenesis in the absence of olfactory function, with the retention of an SVZ-like anatomical region either vestigial or of still unknown role. [ABSTRACT FROM AUTHOR]
Copyright of Brain Structure & Function is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Non-neurogenic SVZ-like niche in dolphins, mammals devoid of olfaction.
|
---|---|
Autor/in / Beteiligte Person: | Parolisi, Roberta ; Cozzi, Bruno ; Bonfanti, Luca |
Link: | |
Zeitschrift: | Brain Structure & Function, Jg. 222 (2017-08-01), Heft 6, S. 2625-2639 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 1863-2653 (print) |
DOI: | 10.1007/s00429-016-1361-3 |
Schlagwort: |
|
Sonstiges: |
|