Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer.
In: Annals of Nuclear Medicine, Jg. 32 (2018-07-01), Heft 6, S. 418-424
Online
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Zugriff:
Objective: To identify prognostic factors associated with a low-iodine diet (LID) and the amount of remnant thyroid tissue in Japanese patients with differentiated thyroid cancer (DTC) who received initial I-131 remnant ablation (RAI) using a fixed low dose of I-131 (1110 MBq). Patients and Methods: In this prospective study, we enrolled 45 patients. Patients were classified into a self-managed LID group and a strict LID group. We measured the urinary iodine concentration on the day of RAI after patients consumed LID for 2 weeks. Thyroid-stimulating hormone-induced thyroglobulin (Tg) levels and I-131 uptake by the remnant thyroid tissue were also evaluated. A response-evaluation whole-body scan (WBS) was performed 6-8 months after RAI to determine the outcome of the therapy. Results: Post-LID urinary iodine levels of the strict LID group tended to be lower than those of the self-managed LID group. Twenty-five cases (56%) showed absence of uptake, whereas 20 cases (44%) showed residual uptake on the response-evaluation WBS. There were no significant differences between "absence" and "residual" groups in urinary iodine concentrations and Tg levels (p = 0.253 and p = 0.234, respectively). However, significant differences were observed in I-131 uptake by the thyroid bed (p = 0.035). Conclusions: For patients following the current Japanese method of a 2-week LID, the urinary iodine concentration was not a predictive factor for the successful outcome of RAI. In contrast, low I-131 uptake by the thyroid bed, revealed by the scintigram after RAI, may serve as a favorable predictive factor. [ABSTRACT FROM AUTHOR]
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Titel: |
Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer.
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Autor/in / Beteiligte Person: | Ito, Shinji ; Iwano, Shingo ; Kato, Katsuhiko ; Naganawa, Shinji |
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Zeitschrift: | Annals of Nuclear Medicine, Jg. 32 (2018-07-01), Heft 6, S. 418-424 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 0914-7187 (print) |
DOI: | 10.1007/s12149-018-1261-0 |
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