Diagnostics of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
In: Journal of Laboratory Medicine / Laboratoriums Medizin, 2015-03-02, S. 1-9
academicJournal
Zugriff:
Myelodysplastic syndromes (MDS) are clonal malignant diseases of the hematopoietic stem cell. They are diagnosed mainly in elderly cytopenic patients and are characterized by a heterogeneous course of the disease. The diagnosis is based on blood and marrow cytology, chromosomal examination, and histology of the marrow, taking into account the degree of dysplasia, peripheral and medullary blast count, and cytogenetic findings according to the proposals of the World Health Organization (WHO) classification. The assessment of cytologic findings is important because the different types of MDS differ in terms of prognosis and therapeutic considerations. Acute myeloid leukemias are discriminated from MDS according to the blast counts in the bone marrow or peripheral blood (≥20%). Diagnosis is based on morphology and cytogenetics, and histology is also important. In addition, immunophenotyping and molecular investigations are needed. Information derived from cytogenetics and molecular markers play an important role for prognostication. Minimal residual disease can be best investigated using immunophenotyping and measurement of molecular markers. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Laboratory Medicine / Laboratoriums Medizin is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Diagnostics of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
|
---|---|
Autor/in / Beteiligte Person: | Germing, Ulrich ; Haferlach, Torsten |
Zeitschrift: | Journal of Laboratory Medicine / Laboratoriums Medizin, 2015-03-02, S. 1-9 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 0342-3026 (print) |
DOI: | 10.1515/labmed-2015-0114 |
Schlagwort: |
|
Sonstiges: |
|