Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality.
In: Nature Communications, Jg. 11 (2020-06-05), Heft 1, S. 1-13
Online
academicJournal
Zugriff:
Virtual memory T (T VM ) cells are antigen-naïve CD8 + T cells that exist in a semi-differentiated state and exhibit marked proliferative dysfunction in advanced age. High spare respiratory capacity (SRC) has been proposed as a defining metabolic characteristic of antigen-experienced memory T (T MEM ) cells, facilitating rapid functionality and survival. Given the semi-differentiated state of T VM cells and their altered functionality with age, here we investigate T VM cell metabolism and its association with longevity and functionality. Elevated SRC is a feature of T VM , but not T MEM , cells and it increases with age in both subsets. The elevated SRC observed in aged mouse T VM cells and human CD8 + T cells from older individuals is associated with a heightened sensitivity to IL-15. We conclude that elevated SRC is a feature of T VM , but not T MEM , cells, is driven by physiological levels of IL-15, and is not indicative of enhanced functionality in CD8 + T cells. Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8 + T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have high SRC, a metabolic state that it is affected by ageing and IL-15 signalling and not directly by FAO. [ABSTRACT FROM AUTHOR]
Copyright of Nature Communications is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality.
|
---|---|
Autor/in / Beteiligte Person: | Quinn, Kylie M. ; Hussain, Tabinda ; Kraus, Felix ; Formosa, Luke E. ; Lam, Wai K. ; Dagley, Michael J. ; Saunders, Eleanor C. ; Assmus, Lisa M. ; Wynne-Jones, Erica ; Loh, Liyen ; van de Sandt, Carolien E. ; Cooper, Lucy ; Good-Jacobson, Kim L. ; Kedzierska, Katherine ; Mackay, Laura K. ; McConville, Malcolm J. ; Ramm, Georg ; Ryan, Michael T. ; La Gruta, Nicole L. |
Link: | |
Zeitschrift: | Nature Communications, Jg. 11 (2020-06-05), Heft 1, S. 1-13 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/s41467-020-16633-7 |
Schlagwort: |
|
Sonstiges: |
|