FARELERDE PRALLETRİNİN TOKSİKOKİNETİĞİ. (Turkish)
In: Journal of Health Sciences / Sağlık Bilimleri Dergisi, Jg. 29 (2020-12-01), Heft 3, S. 5-5
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Zugriff:
In the study, the toxicokinetics of pralletrin applied to Balb C mice at the dose of 2 mg/kg.bw intraperitoneally and orally were investigated. A total of 42, 35-40 grams of 2-3 month old female animals were used. Two groups were assigned and 21 animals were kept in each group. Each mouse in the first group was given intraperitoneally at a dose of 2.0 mg/kg.bw prallethrin in dimethyl sulfoxide. Each mouse in the second group was administered orally at a single dose of 2.0 mg/ kg.bw prallethrin in dimethyl sulfoxide. After intravenously and orally administration of prallethrin, intracardiac blood was drawn into heparinized tubes at 0.083, 0.25, 0.5, 0.75, 1, 2, 4, 6, 8, 12, 18, 24, 36 and 72th hours. Plasma prallethrin concentrations were measured on gas chromatography using a micro electron capture detector. Plasma prallethrin maximum concentration (C max ), maximum concentration time to reach (t max ), half-life (t 1/2β ), mean residence time (MRT), area under the curve (AUC 0→∞ ) and bioavailability (F) values after oral administration, 3.66±0.78 ng/ml, 0.60±0.05 hours, 10.20±1.24 hours, 11.72±1.51 hours, 15.19±4.43 ng/hour.ml and 39.86 %, respectively. Following intraperitoneal administration, t 1/2β , MRT and AUC 0→∞ values were calculated as 7.46±0.54 hours, 8.05±0.64 hours and 38.10±5.80 ng/hour.ml, respectively. The data obtained indicate that the oral bioavailability of the prallethrin is low. The half-life and mean residence time of this pesticide in the body is not short in case of administration for both routes. The results obtained indicate that prallethrin may pose a risk of poisoning at high dose exposure. [ABSTRACT FROM AUTHOR]
Çalışma kapsamında periton içi ve ağ ızdan 2 mğ/kğ.ca dozunda Balb C ırkı farelere uyğulanan pralletrinin toksiko kinetiğ i araştırıldı. Toplam 42 adet 35-40 ğram ağ ırlığ ında 2-3 aylık dişi hayvan kullanıldı. İ ki ğrup oluşturuldu ve her ğrupta 21 adet hayvan bulunduruldu. Birinci ğruptaki her fareye tek sefer 2 mğ/kğ.ca dozunda pralletrin dimetil su lfoksitte periton içi verildi. İ kinci ğruptaki her fareye yine tek sefer 2 mğ/kğ.ca dozunda pralletrin dimetil su lfoksitte sondayla ağ ızdan uyğulandı. Pralletrin verildikten sonra farelerden kalp içi 0,083, 0,25, 0,5, 0,75, 1, 2, 4, 6, 8, 12, 18, 24, 36 ve 72. saatlerde heparinli tu plere kan alındı. Plazma pralletrin du zeyleri ğaz kromatoğrafide mikro elektron yakalama dedekto ru kullanılarak o lçu ldu . Ağ ızdan uyğulamanın ardından plazma pralletrin doruk yoğ unluğu (Y doruk ), doruk değ ere ulaşma su resi (t doruk ),yarılanma o mru (t 1/2β ),ortalama kalış su resi (MRT), eğ rinin altında kalan alan (EAA 0→∞ ) ve biyo yararlanım (F) değ erleri sırasıyla 3,66±0,78 nğ/ml, 0,60±0,05 saat, 10,20±1,24 saat, 11,72±1,51 saat, 15,19±4,43 nğ/saat. ml ve % 39,86 oldu. Periton içi verilme durumunda t 1/2β ,MRT ve EAA 0→∞ değ erleri ise sırasıyla, 7,46±0,54 saat, 8,05±0,64 saat ve 38,10±5,80 nğ/saat.ml hesaplandı. Elde edilen veriler pralletrinin ağ ızdan biyo yararlanımının du şu k du zeyde olduğ unu ğo sterdi. Pestisitin yarılanma o mru ve vu cutta kalış su resi ise her iki yolla verilme durumunda da kısa değ ildi. Elde edilen sonuçlar, pralletrine yu ksek dozdaki maruziyetin zehirleme açısından risk oluşturabileceğ ini ifade etmektedir. [ABSTRACT FROM AUTHOR]
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Titel: |
FARELERDE PRALLETRİNİN TOKSİKOKİNETİĞİ. (Turkish)
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Autor/in / Beteiligte Person: | SOW, Mamadou Bhoye |
Zeitschrift: | Journal of Health Sciences / Sağlık Bilimleri Dergisi, Jg. 29 (2020-12-01), Heft 3, S. 5-5 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1018-3655 (print) |
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