Dynamics of Neutralizing Antibody Titers in the Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
In: Journal of Infectious Diseases, Jg. 223 (2021-01-15), Heft 2, S. 197-205
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Zugriff:
Most individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop neutralizing antibodies that target the viral spike protein. In this study, we quantified how levels of these antibodies change in the months after SARS-CoV-2 infection by examining longitudinal samples collected approximately 30-152 days after symptom onset from a prospective cohort of 32 recovered individuals with asymptomatic, mild, or moderate-severe disease. Neutralizing antibody titers declined an average of about 4-fold from 1 to 4 months after symptom onset. This decline in neutralizing antibody titers was accompanied by a decline in total antibodies capable of binding the viral spike protein or its receptor-binding domain. Importantly, our data are consistent with the expected early immune response to viral infection, where an initial peak in antibody levels is followed by a decline to a lower plateau. Additional studies of long-lived B cells and antibody titers over longer time frames are necessary to determine the durability of immunity to SARS-CoV-2. [ABSTRACT FROM AUTHOR]
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Titel: |
Dynamics of Neutralizing Antibody Titers in the Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
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Autor/in / Beteiligte Person: | Crawford, Katharine H D ; Dingens, Adam S ; Eguia, Rachel ; Wolf, Caitlin R ; Wilcox, Naomi ; Logue, Jennifer K ; Shuey, Kiel ; Casto, Amanda M ; Fiala, Brooke ; Wrenn, Samuel ; Pettie, Deleah ; King, Neil P ; Greninger, Alexander L ; Chu, Helen Y ; Bloom, Jesse D |
Zeitschrift: | Journal of Infectious Diseases, Jg. 223 (2021-01-15), Heft 2, S. 197-205 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1093/infdis/jiaa618 |
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