Magnetic resonance imaging and ultrasound for prediction of residual tumor size in early breast cancer within the ADAPT subtrials.
In: Breast Cancer Research, Jg. 23 (2021-03-18), Heft 1, S. 1-13
Online
academicJournal
Zugriff:
Background: Prediction of histological tumor size by post-neoadjuvant therapy (NAT) ultrasound and magnetic resonance imaging (MRI) was evaluated in different breast cancer subtypes. Methods: Imaging was performed after 12-week NAT in patients enrolled into three neoadjuvant WSG ADAPT subtrials. Imaging performance was analyzed for prediction of residual tumor measuring ≤10 mm and summarized using positive (PPV) and negative (NPV) predictive values. Results: A total of 248 and 588 patients had MRI and ultrasound, respectively. Tumor size was over- or underestimated by < 10 mm in 4.4% and 21.8% of patients by MRI and in 10.2% and 15.8% by ultrasound. Overall, NPV (proportion of correctly predicted tumor size ≤10 mm) of MRI and ultrasound was 0.92 and 0.83; PPV (correctly predicted tumor size > 10 mm) was 0.52 and 0.61. MRI demonstrated a higher NPV and lower PPV than ultrasound in hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-positive and in HR-/HER2+ tumors. Both methods had a comparable NPV and PPV in HR-/HER2- tumors. Conclusions: In HR+/HER2+ and HR-/HER2+ breast cancer, MRI is less likely than ultrasound to underestimate while ultrasound is associated with a lower risk to overestimate tumor size. These findings may help to select the most optimal imaging approach for planning surgery after NAT. Trial Registration: Clinicaltrials.gov , NCT01815242 (registered on March 21, 2013), NCT01817452 (registered on March 25, 2013), and NCT01779206 (registered on January 30, 2013). [ABSTRACT FROM AUTHOR]
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Magnetic resonance imaging and ultrasound for prediction of residual tumor size in early breast cancer within the ADAPT subtrials.
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Autor/in / Beteiligte Person: | Graeser, Monika ; Schrading, Simone ; Gluz, Oleg ; Strobel, Kevin ; Herzog, Christopher ; Umutlu, Lale ; Frydrychowicz, Alex ; Rjosk-Dendorfer, Dorothea ; Würstlein, Rachel ; Culemann, Ralph ; Eulenburg, Christine ; Adams, Jascha ; Nitzsche, Henrik ; Prange, Anna ; Kümmel, Sherko ; Grischke, Eva-Maria ; Forstbauer, Helmut ; Braun, Michael ; Potenberg, Jochem ; von Schumann, Raquel |
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Zeitschrift: | Breast Cancer Research, Jg. 23 (2021-03-18), Heft 1, S. 1-13 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 1465-5411 (print) |
DOI: | 10.1186/s13058-021-01413-y |
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