Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing.
In: Nature Communications, Jg. 12 (2021-05-11), Heft 1, S. 1-12
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Zugriff:
Efficient immune responses rely on heterogeneity, which in CD8 + T cells, amongst other mechanisms, is achieved by asymmetric cell division (ACD). Here we find that ageing, known to negatively impact immune responses, impairs ACD in murine CD8 + T cells, and that this phenotype can be rescued by transient mTOR inhibition. Increased ACD rates in mitotic cells from aged mice restore the expansion and memory potential of their cellular progenies. Further characterization of the composition of CD8 + T cells reveals that virtual memory cells (T VM cells), which accumulate during ageing, have a unique proliferation and metabolic profile, and retain their ability to divide asymmetrically, which correlates with increased memory potential. The opposite is observed for naive CD8 + T cells from aged mice. Our data provide evidence on how ACD modulation contributes to long-term survival and function of T cells during ageing, offering new insights into how the immune system adapts to ageing. Asymmetrical cell division helps to maintain cellular heterogeneity in the T cell compartment. Here the authors examine the differential immune responses built by naive and virtual memory T cells from young and aged individuals, and explore the effect of mTOR inhibition on asymmetrical cell division and memory formation. [ABSTRACT FROM AUTHOR]
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Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing.
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Autor/in / Beteiligte Person: | Borsa, Mariana ; Barandun, Niculò ; Gräbnitz, Fabienne ; Barnstorf, Isabel ; Baumann, Nicolas S. ; Pallmer, Katharina ; Baumann, Samira ; Stark, Dominique ; Balaz, Miroslav ; Oetiker, Nathalie ; Wagen, Franziska ; Wolfrum, Christian ; Simon, Anna Katharina ; Joller, Nicole ; Barral, Yves ; Spörri, Roman ; Oxenius, Annette |
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Zeitschrift: | Nature Communications, Jg. 12 (2021-05-11), Heft 1, S. 1-12 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/s41467-021-22954-y |
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