Comparison Between SonoVue and Sonazoid Contrast‐Enhanced Ultrasound in Characterization of Focal Nodular Hyperplasia Smaller Than 3 cm.
In: Journal of Ultrasound in Medicine, Jg. 40 (2021-10-01), Heft 10, S. 2095-2104
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Zugriff:
Objectives: This study aimed to compare the diagnostic efficacy of contrast‐enhanced ultrasound (CEUS), including SonoVue (SV; sulfur hexafluoride; Bracco SpA, Milan, Italy) and Sonazoid (SZ; perflubutane; GE Healthcare, Oslo, Norway), and explore the differences between them in the characterization of CEUS features in focal nodular hyperplasia (FNH) smaller than 3 cm. Methods: This retrospective study included 31 lesions smaller than 3 cm diagnosed as FNH by CEUS between April 2019 and November 2019. Nine patients underwent SZ CEUS examinations, and 22 patients underwent SV CEUS examinations; all of them were confirmed by pathologic examinations or 2 other kinds of CEUS methods. We compared the CEUS features between SZ and SV in different phases, including arterial, portal venous, delayed, and Kupffer (SZ) phases. Results: Twenty‐eight lesions were eventually diagnosed as FNH; 3 were misdiagnosed as FNH by SV CEUS. The overall diagnostic accuracy of CEUS including SZ and SV was 90.3% (28 of 31). No significant difference was found (P >.05) for the positive predictive value. Likewise, no significant difference in depicting centrifugal filling (9 of 9 versus 19 of 19), spoke wheel artery (6 of 9 versus 8 of 19), or feeding artery (2 of 9 versus 10 of 19) features was found between the contrast agents; However, SZ was significantly better at depicting the presence of a central scar than SV (5 of 9 versus 3 of 19; P =.030). Misdiagnosed cases are discussed in detail. Conclusions: Contrast‐enhanced ultrasound enables an accurate diagnosis in FNH smaller than 3 cm. Sonazoid CEUS and SV CEUS were comparable in diagnosing small FNH, and both agents were highly capable of depicting the centrifugal filling dynamic process of FNH smaller than 3 cm. Sonazoid CEUS might be better than SV CEUS at depicting a central scar. [ABSTRACT FROM AUTHOR]
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Titel: |
Comparison Between SonoVue and Sonazoid Contrast‐Enhanced Ultrasound in Characterization of Focal Nodular Hyperplasia Smaller Than 3 cm.
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Autor/in / Beteiligte Person: | He, Mengna ; Zhu, Lu ; Huang, Min ; Zhong, Liyun ; Ye, Zhengdu ; Jiang, Tian'an |
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Zeitschrift: | Journal of Ultrasound in Medicine, Jg. 40 (2021-10-01), Heft 10, S. 2095-2104 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0278-4297 (print) |
DOI: | 10.1002/jum.15589 |
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