BTL-II : a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse.
In: Immunogenetics, Jg. 51 (2000-04-01), Heft 4/5, S. 373-382
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Zugriff:
Comparison of human and mouse genomic sequence at the border of the major histocompatibility complex (MHC) class II and class III regions revealed a locus encoding six exons with homology to the butyrophilin gene family and the location of a previously decribed gene, testis-specific basic protein (TSBP). We named the new locus BTL-II, for butyrophilin-like MHC class II associated. The six discernable exons of the BTL-II locus encode a small hydrophobic amino acid sequence (which may be a signal peptide), two immunoglobulin domains, a small 7-amino acid, heptad repeat-like exon, and a further two immunoglobulin domains. In mouse, an additional butyrophilin-like gene (NG10) is situated adjacent to BTL-II. Expression studies of the BTL-II locus in mouse showed that it is expressed in a range of gut tissues. We demonstrate that like many other genes from the MHC, BTL-II is polymorphic in a selection of diverse HLA haplotypes. In the light of the newly discovered locus, we revisit and discuss the possible origin of the butyrophilin gene family [ABSTRACT FROM AUTHOR]
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Titel: |
BTL-II : a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse.
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Autor/in / Beteiligte Person: | Stammers, M. ; Rowen, L. ; Rhodes, D. ; Trowsdale, J. ; Beck, S. |
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Zeitschrift: | Immunogenetics, Jg. 51 (2000-04-01), Heft 4/5, S. 373-382 |
Veröffentlichung: | 2000 |
Medientyp: | academicJournal |
ISSN: | 0093-7711 (print) |
DOI: | 10.1007/s002510050633 |
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