Simultaneous measurements of myocardial glucose metabolism and extracellular volumes with hybrid PET/MRI using concurrent injections of Gd-DTPA and [<superscript>18</superscript>F]FDG.
In: Journal of Nuclear Cardiology, Jg. 29 (2022-06-01), Heft 3, S. 1304-1314
Online
academicJournal
Zugriff:
Background: The aims of this study were to investigate the application of a constant infusion (CI) to mitigate the issue of constantly changing Gd-DTPA contrast levels in a bolus injection for extracellular volume (ECV) measurements by (a) comparing a CI alone to a bolus alone and a bolus followed by CI in healthy myocardium, (b) evaluating the impact of glucose suppression using heparin on ECV. Methods: Five healthy canine subjects were imaged to compare three different protocols for injecting Gd-DTPA and FDG: bolus alone, CI alone, bolus followed by CI. Suppression of myocardial glucose uptake was induced using a continuous infusion of 20% lipid at a rate of 0.25 mL·min −1 ·kg −1 as well as 2000 units of intravenous heparin injected 20 minutes prior to FDG/Gd-DTPA injection. Results: There was no significant effect on ECV measurement when heparin was used for glucose suppression at equilibrium irrespective of infusion protocol). Measurements of ECV in myocardium, regardless of infusion protocol showed no significant difference at all time points (P = 0.21) prior to washout. Conclusions: The suppression of myocardial uptake of [ 18 F]FDG with heparin did not alter the determination of myocardial ECV though a larger sample size may show differences. Further, the infusion protocol (bolus or constant infusion) had no effect on the calculated ECV. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Nuclear Cardiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Simultaneous measurements of myocardial glucose metabolism and extracellular volumes with hybrid PET/MRI using concurrent injections of Gd-DTPA and [<superscript>18</superscript>F]FDG.
|
---|---|
Autor/in / Beteiligte Person: | Smailovic, H. ; Wilk, B. ; Wisenberg, G. ; Sykes, J. ; Butler, J. ; Hicks, J. ; Thiessen, J. D. ; Prato, F. S. |
Link: | |
Zeitschrift: | Journal of Nuclear Cardiology, Jg. 29 (2022-06-01), Heft 3, S. 1304-1314 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1071-3581 (print) |
DOI: | 10.1007/s12350-020-02486-6 |
Sonstiges: |
|