Cyclosporin A Inhibits a Discrete Step in T-Lymphocyte Stimulation.
In: Scandinavian Journal of Immunology, Jg. 22 (1985-09-01), Heft 3, S. 279-284
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Zugriff:
Cyclosporin A (CyA) interferes with immune responses and prevents growth factor release by stimulated T cells. However, it is not known whether this is due to an effect on the accessory cells, required for T-cell responses, whether antigen recognition cannot occur, or whether later steps, leading to lymphokine production, are blocked. For this reason, the effect of CyA on homogeneous populations of T tumour cells was investigated. The immunosuppressive compound efficiently prevented T-cell growth factor (TCGF) (interleukin 2) release by stimulated tumour cells. Still, the cells retained the surface antigen T.V known to be involved in T-cell stimulation, after treatment with CyA. Furthermore, CyA failed to affect the inhibition of proliferation, observed in a T-cell tumour in response to stimulation, indicating that the cells had received the stimulatory impetus. TCGF release, induced by treatment with a phorbol ester, was only partly sensitive to inhibition by CyA, demonstrating that CyA will interfere with discrete aspects of the stimulation of a T-cell. [ABSTRACT FROM AUTHOR]
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Titel: |
Cyclosporin A Inhibits a Discrete Step in T-Lymphocyte Stimulation.
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Autor/in / Beteiligte Person: | Landegren, U. ; Wigzell, H. |
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Zeitschrift: | Scandinavian Journal of Immunology, Jg. 22 (1985-09-01), Heft 3, S. 279-284 |
Veröffentlichung: | 1985 |
Medientyp: | academicJournal |
ISSN: | 0300-9475 (print) |
DOI: | 10.1111/j.1365-3083.1985.tb01882.x |
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