Success of nano-vaccines against COVID-19: a transformation in nanomedicine.
In: Expert Review of Vaccines, Jg. 21 (2022-12-01), Heft 12, S. 1739-1761
academicJournal
Zugriff:
The vaccines being used against COVID-19 are composed of either non-viral or viral nanoparticles (NPs). Nanotechnology-based vaccine technology was studied for its potentially transformative advancement of medicine. NPs protect the encapsulated mRNA in vaccines, thereby enhancing the stability of the ribonucleic acids and facilitating their intact delivery to their specific targets. Compared to liposomes, lipid nanoparticles (LNPs) are unique and, through their rigid morphology and better cellular penetrability, render enhanced cargo stability. To explore nanotechnology-mediated vaccine delivery and its potential in future pandemics, we assessed articles from various databases, such as PubMed, Embase, and Scopus, including editorial/research notes, expert opinions, and collections of data from several clinical research trials. In the current review, we focus on the nanoparticulate approach of the different SARS-CoV-2 vaccines and explore their success against the pandemic. The mRNA-based vaccines, with their tremendous efficacy of ~95% (under phase III-IV clinical trials) and distinct nanocarriers (LNPs), represent a new medical front alongside DNA and siRNA-based vaccines. [ABSTRACT FROM AUTHOR]
Copyright of Expert Review of Vaccines is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Success of nano-vaccines against COVID-19: a transformation in nanomedicine.
|
---|---|
Autor/in / Beteiligte Person: | Sarangi, Manoj Kumar ; Padhi, Sasmita ; Rath, Gautam ; Nanda, Sitansu Sekhar ; Yi, Dong Kee |
Zeitschrift: | Expert Review of Vaccines, Jg. 21 (2022-12-01), Heft 12, S. 1739-1761 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1476-0584 (print) |
DOI: | 10.1080/14760584.2022.2148659 |
Schlagwort: |
|
Sonstiges: |
|