A Packaged Multiplexed Fluorescent Biomolecular Sensor Array and Ultralow-Power Wireless Interface in CMOS for Ingestible Electronic Applications.
In: IEEE Sensors Journal, Jg. 22 (2022-12-15), Heft 24, S. 24060-24074
Online
academicJournal
Zugriff:
Ingestible electronics capable of laboratory quality biomolecular analysis occupying pill-sized volume, operating at sub-mW with a robust wireless interface can transform medical diagnostics and personalized healthcare. Miniaturization of complex biomolecular systems in such a volume is extremely challenging, including a wireless interface that is capable of robust communication through inches of tissue. This article presents for the first time a fully packaged biosensor system with transmitter (Tx)/receiver (Rx) antennas coupled to a single CMOS chip that integrates a low-power wireless interface and a 15-pixel fluorescence biosensor array with on-chip nanoplasmonic optical filters. The IC, operating across multiple industrial, scientific, and medical (ISM)/medical implant communication system (MICS) bands, employs pulse-pause-encoded ASK/OOK modulation, and achieves reception energy efficiency of 28 pJ/bit at 7 Mb/s and −58 dBm of sensitivity with $196 \mu \text{W}$ of dc power. The entire biocompatible package is miniaturized to a size of 1.2 $\times $ 2.5 cm2. To the best of the authors’ knowledge, this work demonstrates for the first time a packaged bio-pill with in situ biomolecular sensing and quantification with pM sensitivity in CMOS ICs that also encompasses wireless transmission capability through inches of tissue at state-of-the-art energy efficiency. [ABSTRACT FROM AUTHOR]
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Titel: |
A Packaged Multiplexed Fluorescent Biomolecular Sensor Array and Ultralow-Power Wireless Interface in CMOS for Ingestible Electronic Applications.
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Autor/in / Beteiligte Person: | Zhu, Chengjie ; Hong, Lingyu ; Yang, Haw ; Sengupta, Kaushik |
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Zeitschrift: | IEEE Sensors Journal, Jg. 22 (2022-12-15), Heft 24, S. 24060-24074 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1530-437X (print) |
DOI: | 10.1109/JSEN.2022.3216455 |
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