Biochemical and Histopathological Investigation of the Protective Effect of Lutein in Rat Kidney Exposed to Cisplatin.
In: Medical Records, Jg. 4 (2022-09-01), Heft 3, S. 433-438
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Zugriff:
Aim: The aim of this study was to determine the protection of lutein (L) (100 mg/kg, orally) against kidney damage caused by cisplatin (Cis) (10mg/kg, intraperitoneal). Materials and Methods: Twenty-eight rats aged 8 weeks were used and divided into four equal groups (n=7): Control, L, Cis, and Cis + L. Results: As a result of biochemical findings, serum Cr and BUN levels of the Cis group were significantly increased compared to the control group (p<0.05). Serum Cr and BUN levels of the Cis + L group were found to be significantly reduced compared to the Cis group (p<0.05). In addition, a decrease in MDA level and an increase in GSH, SOD and CAT levels were detected in the Cis + L group compared to the Cis group (p<0.05). In the histopathological examinations, in the Cis group kidney tissues; pathological changes such as interstitial mononuclear leukocyte infiltration, tubular degeneration, and tubular necrosis were observed. When the Cis + L group is compared with the Cis group, it can be said that there is a decrease in oxidative stress, an increase in antioxidant activity and a decrease in histopathological changes with the effect of L. Conclusion: These results show that L is effective in preventing Cis-induced kidney injury. It is also emerging that L is a pharmacological agent with the potential to be used in this damage. [ABSTRACT FROM AUTHOR]
Amaç: Çalışmamızda, sisplatin (Cis) (10mg/kg, intraperitoneal) kaynaklı böbrek hasarına karşı lutein'in (L) (100mg/kg, oral) koruyucu etkisi incelendi. Materyal ve Metot: Bu çalışma, 8 haftalık 28 adet sıçanla gerçekleştirildi. Oluşturulan 4 grubun her birinde 7 tane sıçan yer aldı: Kontrol, L, Cis ve Cis + L. Bulgular: Biyokimyasal bulgulara göre, Cis grubunun kontrol grubu ile kıyaslanmasında serum Cr ve BUN seviyelerinin anlamlı düzeyde arttığı görüldü (p<0.05). Cis + L grubunda serum Cr ve BUN düzeylerinin Cis grubuna kıyasla anlamlı düzeyde azaldığı tespit edildi (p<0.05). Ayrıca Cis + L grubunun Cis grubu ile kıyaslanmasında MDA seviyesinde düşüş, GSH, SOD ve CAT seviyelerinde ise artış kaydedildi (p<0.05). Yapılan histopatolojik incelemelerde Cis grubu sıçanların böbrek dokularında interstisyel mononükleer lökosit infiltrasyonu, tubuler dejenerasyon ve tubuler nekroz gibi patolojik değişiklikler gözlendi. Cis + L grubu Cis grubu ile kıyaslandığında L'nin etkisi ile oksidatif streste bir azalma, antioksidan aktivitede bir artma ve histopatolojik değişikliklerde bir azalma olduğu söylenebilir. Sonuç: Bu sonuçlar L'nin Cis kaynaklı böbrek hasarının önlenmesinde etkili olduğunu göstermektedir. Ayrıca L'nin bu hasarda kullanılma potansiyeli olan bir farmakolojik ajan olduğuda ortaya çıkmaktadır. [ABSTRACT FROM AUTHOR]
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Titel: |
Biochemical and Histopathological Investigation of the Protective Effect of Lutein in Rat Kidney Exposed to Cisplatin.
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Autor/in / Beteiligte Person: | Bilgic, Sedat ; Gur, Fatih M. ; Aktas, Ibrahim |
Zeitschrift: | Medical Records, Jg. 4 (2022-09-01), Heft 3, S. 433-438 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 2687-4555 (print) |
DOI: | 10.37990/medr.1142424 |
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