Split phenomena in amyotrophic lateral sclerosis: Current evidences, pathogenetic hypotheses and diagnostic implications.
In: Frontiers in Neuroscience, Jg. 16 (2023-01-09), S. 1-12
Online
academicJournal
Zugriff:
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease and has emerged among the disorders with the largest increasing incidence in Western countries. Although the diagnosis is based on clinical grounds, electromyography (EMG), and nerve conduction studies (NCS) play a crucial role to exclude other potential etiologies of lower motor neuron (LMN) dysfunction. Based on clinical grounds, a peculiar pattern of dissociated atrophy of the intrinsic hand and foot muscles, termed the "split-hand" (SH) and "split-leg" (SL) signs, has been described in a significant proportion of subjects with ALS, even at the early stages of the disease, when symptoms are focal. These signs are rare in neurological and non-neurological diseases other than ALS. In this review, we discussed current evidences concerning SH and SL signs, their pathogenetic hypotheses and neurophysiological findings. We also analyze whether SH and SL signs can be reliable markers in the differential diagnosis and in the prognosis of ALS. [ABSTRACT FROM AUTHOR]
Copyright of Frontiers in Neuroscience is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Split phenomena in amyotrophic lateral sclerosis: Current evidences, pathogenetic hypotheses and diagnostic implications.
|
---|---|
Autor/in / Beteiligte Person: | Zoccolella, Stefano ; Giugno, Alessia ; Logroscino, Giancarlo |
Link: | |
Zeitschrift: | Frontiers in Neuroscience, Jg. 16 (2023-01-09), S. 1-12 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1662-4548 (print) |
DOI: | 10.3389/fnins.2022.1100040 |
Schlagwort: |
|
Sonstiges: |
|