The Value of Immunocytochemical Staining for the HPV E7 Protein in the Diagnosis of Cervical Lesions.
In: International Journal of General Medicine, Jg. 16 (2023-03-01), S. 1081-1089
Online
academicJournal
Zugriff:
aimiao Xu, 2 Fang Liu 3 1 Department of Pathology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, People's Republic of China; 2 Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, People's Republic of China; 3 Department of Gynecology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, People's Republic of ChinaCorrespondence: Mingjian Fei, Department of Pathology, The Second Hospital of Jiaxing, 1518 Huanchen North Road, Jiaxing, Zhejiang, 314000, People's Republic of China, Email [email protected] Purpose: To investigate the value of immunocytochemical (ICC) staining for human papillomavirus (HPV) E7 protein (E7-ICC staining) as a new-generation immunological method in the cytological diagnosis of cervical lesions. Methods: The exfoliated cervical cell samples of 690 women were subjected to a liquid-based cytology test (LCT), high-risk HPV (HR-HPV) test, E7-ICC staining, and cervical biopsy for pathological diagnosis. Results: E7-ICC staining as a preliminary screening scheme for cervical precancerous lesions was comparable to the HR-HPV test in sensitivity and to the LCT in specificity. E7-ICC staining was advantageous in facilitating the secondary triage of HR-HPV-positive patients; therefore, this method can be used as an auxiliary scheme to routine LCT for diagnostic grading to improve the accuracy of cervical cytology. Conclusion: E7-ICC staining as a primary or auxiliary cytological screening scheme can effectively reduce the colposcopy referral rate. [ABSTRACT FROM AUTHOR]
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Titel: |
The Value of Immunocytochemical Staining for the HPV E7 Protein in the Diagnosis of Cervical Lesions.
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Autor/in / Beteiligte Person: | Fei, Mingjian ; Yu, Yawei ; Hu, Xiaolan ; Xu, Haimiao ; Liu, Fang |
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Zeitschrift: | International Journal of General Medicine, Jg. 16 (2023-03-01), S. 1081-1089 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1178-7074 (print) |
DOI: | 10.2147/IJGM.S402759 |
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