肾小球肾炎血清 BUN、RBP 的诊断价值分析. (Chinese)

Objective: To study Analysis of the Expression and significance of Urea nitrogen (BUN) and RBP in serum of children with glomerulonephritis. Methods: 75 cases of children with glomerulonephritis admitted to our hospital from January 2018 to January2021 were selected as the subjects of this study, and 55 cases of children with glomerulonephritis who underwent physical examination in our hospital during the same period were selected as the control group. The changes of serum BUN and RBP levels and their diagnostic value were analyzed. Results: The serum BUN and RBP levels of experimental group (15.52 ±1.51 mmol/L, 97.87±21.28 mg/L) were significantly higher than those of control group (5.07±0.97 mmol/L, 42.17±10.25 mg/L), and the differences were significant (P<0.05). The serum BUN and RBP levels of severe glomerulonephritis (19.01±1.20 mmol/L, 118.83±21.24 mg/L) were significantly higher than those of mild glomerulonephritis (11.56±1.07mmol/L, 71.24±19.87) Mg/L), moderate glomerulonephritis (14.89±1.12mmol/L, 95.75±22.13 mg/L), the difference was significant (P<0.05); The serum BUN and RBP levels in children with moderate glomerulonephritis (14.89 ±1.12 mmol/L, 95.75 ±22.13 mg/L) were significantly higher than those in children with mild glomerulonephritis (11.56 ±1.07mmol/L, 71.24±19.87 mg/L), and the differences were significant (P<0.05). The AUC of GLOMERulonephritis diagnosed by BUN was 0.866, 95%CI was 0.807-0.926, and the cut-off value was 8.45 mmol/L. The AUC of RBP in diagnosing glomerulonephritis was0.957, 95%CI was 0.927-0.987, and truncation value was 57.29 mg/L. The AUC and 95%CI for the diagnosis of glomerulonephritis were0.991 and 0.980-1.000, respectively. There were significant differences in the area under the curve between single detection and combined detection (Z=4.11, 2.150, P<0.05). The specificity and accuracy of combined detection were 93.41% and 94.15%, respectively. Conclusion: There is a close relationship between the expression of serum BUN and RBP and the severity of the disease in children with glomerulonephritis. [ABSTRACT FROM AUTHOR]

目的: 探討腎小球腎炎血清中尿素氮 (BUN)、視黃醇結合蛋白 (RBP) 的表達及意義. 方法: 選擇2018年1月至2021年1月大華醫院和我院接診的75例腎小球腎炎患者為本研究對象, 設為試驗組, 另選擇同期在我院體檢的55例作為對照組, 分析血清BUN、RBP水平變化情況, 及其診斷價值. 結果: 試驗組患者血清BUN、RBP水平 (15.52±1.51 mmol/L、97.87±21.28 mg/L) 顯著高于對照組 (5.07±0.97 mmol/L、42.17±10.25 mg/L), 差異顯著 (P<0.05); 重度腎小球腎炎患者血清BUN、RBP水平 (19.01±1.20mmol/L、118.83±21.24 mg/L) 均顯著高于輕度 (11.56±1.07 mmol/L、71.24±19.87 mg/L) 、中度腎小球腎炎患者 (14.89±1.12 mmol/L、95.75±22.13 mg/L), 差異顯著 (P<0.05); 中度腎小球腎炎患者血清BUN、RBP水平 (14.89±1.12 mmol/L、95.75±22.13 mg/L) 均顯著高于輕度腎小球腎炎患者 (11.56±1.07 mmol/L、71.24±19.87 mg/L), 差異顯著 (P<0.05); BUN診斷腎小球腎炎的AUC為0.866,95%CI為0.807~0.926, 截斷值為8.45 mmol/L; RBP診斷腎小球腎炎的AUC為0.957,95%CI為0.927~0.987, 截斷值為57.29 mg/L; 聯合檢測診斷腎小球腎炎的AUC為0.991,95%CI為0.980~1.000, 單獨檢測分別和聯合檢測曲線下面積比較均具有顯著差異 (Z=4.11、2.150,P<0.05); 聯合檢測的特異度、準確度分別為93.41%、94.15%. 結論: 在腎小球腎炎患者中血清BUN、RBP的表達和病情嚴重程度之間存在著密切關系, 可作為診斷腎小球腎炎的重要指標. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)