Congenital Prepubic Sinus as a Variant of Incomplete Urethral Dorsal Duplication: A Case Report with New Insights into its Immunohistochemical Characterization and a Comprehensive Literature Review.
In: International Journal of Surgical Pathology, Jg. 31 (2023-08-01), Heft 5, S. 680-688
academicJournal
Zugriff:
Congenital prepubic sinus (PS) is an extremely infrequent malformation consisting of a prepubic fistulous tract that classically does not communicate with the genitourinary system. Previous studies centered on its immunohistochemical characterization have shown inconsistent results, and the etiology has not been clarified. We present the case of a 2-year-old male who presented since birth with a fistulous orifice on the dorsum of the penis. He had no associated symptoms. Under general anesthesia, the fistulous tract was explored, and methylene blue was instilled through it. After cystoscopically verifying the absence of communication with the urethra, a complete resection of the lesion was performed. The immunohistochemical study showed positivity for low and high molecular weight keratins and a transitional pattern for keratin 7 and GATA3, with positivity at cul de sac level and negativity at proximal level. These findings suggest that this lesion is an incomplete dorsal duplication variant. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Surgical Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Congenital Prepubic Sinus as a Variant of Incomplete Urethral Dorsal Duplication: A Case Report with New Insights into its Immunohistochemical Characterization and a Comprehensive Literature Review.
|
---|---|
Autor/in / Beteiligte Person: | Arredondo Montero, Javier ; Bronte Anaut, Mónica ; Ayuso González, Lidia ; Hernández-Martín, Sara ; Montes, Marta ; Guarch Troyas, Rosa ; Bardají Pascual, Carlos |
Zeitschrift: | International Journal of Surgical Pathology, Jg. 31 (2023-08-01), Heft 5, S. 680-688 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1066-8969 (print) |
DOI: | 10.1177/10668969221117239 |
Schlagwort: |
|
Sonstiges: |
|