Virtual memory T cells orchestrate extralymphoid responses conducive to resident memory.
In: Science Immunology, Jg. 6 (2021-08-01), Heft 62, S. 1-14
academicJournal
Zugriff:
A virtual memory T cell spectrum: Virtual memory T (T VM ) cells that acquire a memory phenotype in the absence of foreign antigen are believed to develop in response to self-antigen exposure, but their roles in protective immunity against foreign pathogens are not well understood. Using specific pathogen–free mice infected with influenza A virus, Hou et al. demonstrate that T VM cells rapidly infiltrate the lungs in a CXCR3-dependent manner, where they expand and promote early viral control. Compared with naïve T cells, T VM cells more efficiently gave rise to resident memory cells, with CCR2 + and CCR2 − subsets poised for effector and memory responses, respectively. These results demonstrate that T VM cells undergo functional specialization and highlight how self-reactive T cells can productively contribute to antigen-specific responses against invading pathogens. A primary immune response is initiated in secondary lymphoid organs. Virtual memory CD8 + T (T VM ) cells are antigen-inexperienced T cells of a central memory phenotype, acquired through self-antigen–driven homeostatic proliferation. Unexpectedly, we find that T VM cells are composed of CCR2 + and CCR2 − subsets that differentially elaborate a spectrum of effector- and memory-poised functions directly in the tissue. During a primary influenza infection, T VM cells rapidly infiltrate the lungs in the first day after infection and promote early viral control. T VM cells that recognize viral antigen are retained in the tissue, clonally expand independent of secondary lymphoid organs, and give rise to tissue-resident memory cells. By orchestrating an extralymphoid primary response, heterogenous T VM cells bridge innate reaction and adaptive memory directly in the infected tissue. [ABSTRACT FROM AUTHOR]
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Titel: |
Virtual memory T cells orchestrate extralymphoid responses conducive to resident memory.
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Autor/in / Beteiligte Person: | Hou, Shiyue ; Shao, Tiange ; Mao, Tianyang ; Shi, Jingwen ; Sun, Jiahui ; Mei, Miao ; Tan, Xu ; Qi, Hai |
Zeitschrift: | Science Immunology, Jg. 6 (2021-08-01), Heft 62, S. 1-14 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 2470-9468 (print) |
DOI: | 10.1126/sciimmunol.abg9433 |
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