DBU-catalyzed Michael additions of bulky glycine imine to β-arylfuryl substituted α,β-unsaturated esters.
In: Synthetic Communications, Jg. 53 (2023-10-20), Heft 19, S. 1637-1646
academicJournal
Zugriff:
DBU-catalyzed Michael reactions between tert-butyl 2-((diphenylmethylene) amino)acetate and simple β-substituted α,β-unsaturated esters have been achieved in high yields (up to 95% yield) and diastereoselectivties (up to 99:1 dr) in the presence of 1.0 eq. of LiBr in acetonitrile under room temperature. The Michael adduct can be easily converted into trans-3-substituted pyroglutamic acid ester through in-situ acidic hydrolysis following lactamation. [ABSTRACT FROM AUTHOR]
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Titel: |
DBU-catalyzed Michael additions of bulky glycine imine to β-arylfuryl substituted α,β-unsaturated esters.
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Autor/in / Beteiligte Person: | Cheng, Mei-Ling ; Wang, Xue-Ying ; Bai, Yu-Jun ; Zhu, Si-Kai ; Zhang, Sheng-Yong ; Bao, Guo-Qiang ; Wang, Ping-An |
Zeitschrift: | Synthetic Communications, Jg. 53 (2023-10-20), Heft 19, S. 1637-1646 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 0039-7911 (print) |
DOI: | 10.1080/00397911.2023.2240450 |
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