Beyond the Concepts of Elder and Marginal in DCD Liver Transplantation: A Prospective Observational Matched-Cohort Study in the Italian Clinical Setting.
In: Transplant International, 2023-09-20, S. 1-8
Online
academicJournal
Zugriff:
Donation after circulatory determination of death (DCD) is a valuable strategy to increase the availability of grafts for liver transplantation (LT). As the average age of populations rises, the donor pool is likely to be affected by a potential increase in DCD donor age in the near future. We conducted a prospective cohort study to evaluate post-transplantation outcomes in recipients of grafts from elderly DCD donors compared with younger DCD donors, and elderly donors after brainstem determination of death (DBD). From August 2020 to May 2022, consecutive recipients of deceased donor liver-only transplants were enrolled in the study. DCD recipients were propensity score matched 1:3 to DBD recipients. One-hundred fifty-seven patients were included, 26 of whom (16.6%) were transplanted with a DCD liver graft. After propensity score matching and stratification, three groups were obtained: 15 recipients of DCD donors ≥75 years, 11 recipients of DCD donors <75 years, and 28 recipients of DBD donors ≥75 years. Short-term outcomes, as well as 12 months graft survival rates (93.3%, 100%, and 89.3% respectively), were comparable among the groups. LT involving grafts retrieved from very elderly DCD donors was feasible and safe in an experienced high-volume center, with outcomes comparable to LTs from younger DCD donors and age-matched DBD donors. [ABSTRACT FROM AUTHOR]
Copyright of Transplant International is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Beyond the Concepts of Elder and Marginal in DCD Liver Transplantation: A Prospective Observational Matched-Cohort Study in the Italian Clinical Setting.
|
---|---|
Autor/in / Beteiligte Person: | Fallani, Guido ; Stocco, Alberto ; Siniscalchi, Antonio ; Velia Antonini, Marta ; Pasquale Stella, Adriano ; Amato, Alessio ; Prosperi, Enrico ; Turco, Laura ; Morelli, Maria Cristina ; Cescon, Matteo ; Ravaioli, Matteo |
Link: | |
Zeitschrift: | Transplant International, 2023-09-20, S. 1-8 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 0934-0874 (print) |
DOI: | 10.3389/ti.2023.11697 |
Schlagwort: |
|
Sonstiges: |
|