A paradoxical population structure of var DBLa types in Africa.
In: Zika & Mosquito Week, 2023-11-24, S. 965-965
serialPeriodical
Zugriff:
This article discusses a study on the population structure of var DBLa types in Africa. The var multigene family encodes the P. falciparum erythrocyte membrane protein 1 (PfEMP1), which is important in host-parasite interaction and responsible for maintaining chronic infection. The study explores the conservation of individual DBL types at different scales in Sub-Saharan Africa and finds that the population structure consists of variants occurring at rare, moderate, and high frequencies. The composition of DBL types within each isolate repertoire reveals a mix of types found at different frequencies in the population. The article also discusses the adaptive forces and balancing selection that may shape the evolution and diversity of DBL types in Africa. [Extracted from the article]
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A paradoxical population structure of var DBLa types in Africa.
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Zeitschrift: | Zika & Mosquito Week, 2023-11-24, S. 965-965 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
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