Kunming Medical University Researchers Add New Data to Research in Borrelia burgdorferi (A key protein from Borrelia burgdorferi could stimulate cytokines in human microglial cells and inhibitory effects of Cucurbitacin IIa).
In: Genomics & Genetics Weekly, 2023-12-08, S. 740-740
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Zugriff:
A recent study conducted by researchers at Kunming Medical University in China explored the pathogenesis of Lyme neuroborreliosis (LNB), an infectious disease of the nervous system caused by Borrelia burgdorferi (Bb) infection. The researchers used recombinant BmpA (rBmpA) to stimulate human microglia cells and found that it led to the production of inflammation-related cytokines. Specifically, six cytokines (IL-6, IL-8, CCL2, CCL5, CXCL1, and CXCL10) showed increased mRNA transcription and three cytokines (IL-6, IL-8, and CXCL10) had significantly increased concentrations in the cell supernatant. The researchers also discovered that Cucurbitacin IIa (CuIIa) could inhibit the expression of these cytokines. This study suggests that the BmpA protein may play a role in the development of LNB through the stimulation of cytokine production, and CuIIa may have potential therapeutic effects on LNB by inhibiting cytokine production in microglia. [Extracted from the article]
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Kunming Medical University Researchers Add New Data to Research in Borrelia burgdorferi (A key protein from Borrelia burgdorferi could stimulate cytokines in human microglial cells and inhibitory effects of Cucurbitacin IIa).
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Zeitschrift: | Genomics & Genetics Weekly, 2023-12-08, S. 740-740 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6467 (print) |
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