Menopausal hormone therapy use and risk of ovarian cancer by race: the ovarian cancer in women of African ancestry consortium.
In: British Journal of Cancer, Jg. 129 (2023-12-07), Heft 12, S. 1956-1967
Online
academicJournal
Zugriff:
Background: Most studies examining post-menopausal menopausal hormone therapy (MHT) use and ovarian cancer risk have focused on White women and few have included Black women. Methods: We evaluated MHT use and ovarian cancer risk in Black (n = 800 cases, 1783 controls) and White women (n = 2710 cases, 8556 controls), using data from the Ovarian Cancer in Women of African Ancestry consortium. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association of MHT use with ovarian cancer risk, examining histotype, MHT type and duration of use. Results: Long-term MHT use, ≥10 years, was associated with an increased ovarian cancer risk for White women (OR = 1.38, 95%CI: 1.22–1.57) and the association was consistent for Black women (OR = 1.20, 95%CI: 0.81–1.78, p interaction = 0.4). For White women, the associations between long-term unopposed estrogen or estrogen plus progesterone use and ovarian cancer risk were similar; the increased risk associated with long-term MHT use was confined to high-grade serous and endometroid tumors. Based on smaller numbers for Black women, the increased ovarian cancer risk associated with long-term MHT use was apparent for unopposed estrogen use and was predominately confined to other epithelial histotypes. Conclusion: The association between long-term MHT use and ovarian cancer risk was consistent for Black and White women. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Cancer is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Menopausal hormone therapy use and risk of ovarian cancer by race: the ovarian cancer in women of African ancestry consortium.
|
---|---|
Autor/in / Beteiligte Person: | Petrick, Jessica L. ; Joslin, Charlotte E. ; Johnson, Courtney E. ; Camacho, T. Fabian ; Peres, Lauren C. ; Bandera, Elisa V. ; Barnard, Mollie E. ; Beeghly, Alicia ; Bethea, Traci N. ; Dempsey, Lauren F. ; Guertin, Kristin ; Harris, Holly R. ; Moorman, Patricia G. ; Myers, Evan R. ; Ochs-Balcom, Heather M. ; Rosenow, Will ; Setiawan, V. Wendy ; Wu, Anna H. ; Schildkraut, Joellen M. ; Rosenberg, Lynn |
Link: | |
Zeitschrift: | British Journal of Cancer, Jg. 129 (2023-12-07), Heft 12, S. 1956-1967 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 0007-0920 (print) |
DOI: | 10.1038/s41416-023-02407-7 |
Sonstiges: |
|