Findings on Non-Small Cell Lung Cancer Detailed by Investigators at Hospital del Mar (Comprehensive Ngs Profiling To Enable Detection of alk Gene Rearrangements and met Amplifications In Non-small Cell Lung Cancer).
In: Cancer Weekly, 2023-12-19, S. 388-388
serialPeriodical
Zugriff:
A recent study conducted at Hospital del Mar in Barcelona, Spain, explored the use of next-generation sequencing (NGS) for detecting gene rearrangements and copy number alterations in non-small cell lung cancer (NSCLC). The study found that the DNA-based NGS assay was highly sensitive in detecting ALK rearrangements and MET copy number alterations. However, some discrepancies were observed, likely due to differences in algorithms and reporting thresholds. The study also assessed tumor mutational burden (TMB) and found that it was significantly lower in cases with NGS-confirmed driver mutations. Overall, the study validates NGS as an accurate approach for detecting structural variants in NSCLC, while also highlighting the need for further optimization to ensure consistency across methodologies. [Extracted from the article]
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Findings on Non-Small Cell Lung Cancer Detailed by Investigators at Hospital del Mar (Comprehensive Ngs Profiling To Enable Detection of alk Gene Rearrangements and met Amplifications In Non-small Cell Lung Cancer).
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Zeitschrift: | Cancer Weekly, 2023-12-19, S. 388-388 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 1071-7218 (print) |
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