紫癜性肾炎患儿血清 Gd-IgA1、sFlt-1、IgA/C3 比值与肾损伤 和疗效的关系研究. (Chinese)

Objective: To investigate the relationship between serum galactose-deficient immunoglobulin A1 (Gd IgA1), soluble fms like tyrosine kinase receptor l (sFlt-1), immunoglobulin A (IgA) /complement C3 (C3) ratio, renal injury, and therapeutic effect in children with purpura nephritis (HSPN) . Methods: A total of 151 children diagnosed with HSPN in the The Affiliated Hospital of Chengdu University were selected from December 2019 to December 2021 as the case group. Another 100 healthy volunteer children who underwent physical examinations during the same period were selected as the control group. The serum Gd-IgA1, sFlt-1, IgA/C3 ratio, renal function index [urea nitrogen (BUN), blood creatinine (Scr), 24 h urinary protein (UP) quantification (24hUPE) and UP/Scr] between the two groups were compared. Pearson correlation analysis was used to investigate the correlation between serum Gd-IgA1, sFlt-1, IgA/C3ratio and renal function indicators. The serum Gd-IgA1, sFlt-1, and IgA/C3 ratios of children with different renal pathological grades and different therapeutic effects were compared. Results: The Gd-IgA1, sFlt-1, IgA/C3 ratio, BUN, Scr, 24hUPE and UP/Scr of the case group were all higher than those of the control group (P＜0.05) . Pearson correlation analysis showed: Gd-IgA1, sFlt-1, IgA/C3 ratios were positively correlated with BUN, Scr, 24hUPE and UP/Scr (P＜0.05) . With the elevated renal pathological grade, the serum Gd-IgA1,sFlt-1, and IgA/C3 ratios in HSPN patients continue to increase (P＜0.05) . The Gd-IgA1, sFlt-1, and IgA/C3 ratios of the invalid group were higher than those of the valid group (P＜0.05) . Conclusion: Gd-IgA1, sFlt-1, and IgA/C3 ratios are involved in the disease progression in children with HSPN, which can lead to renal injury, aggravate renal pathological changes, clinical guidance for treatment can be based on changes in the above indicators. [ABSTRACT FROM AUTHOR]

目的：探讨紫癜性肾炎 (HSPN) 患儿血清半乳糖缺陷免疫球蛋白 A1 (Gd-IgA1) 、可溶性 fms- 样酪氨酸激酶受体 (l sFlt-1) 、免 疫球蛋白 A (IgA) / 补体 C3 (C3) 比值与肾损伤和疗效的关系。方法：选取成都大学附属医院 2019 年 12 月至 2021 年 12 月确诊为 HSPN 的 151 例患儿作为病例组。另选取同期体检健康的志愿儿童 100 例作为对照组。对比两组血清 Gd-IgA1、sFlt-1、IgA/C3 比 值、肾功能指标[尿素氮 (BUN) 、血肌酐 (Scr) 、24 h 尿蛋白 (UP) 定量 (24hUPE) 和 UP/Scr]。采用 Pearson 法分析血清 Gd-IgA1、 sFlt-1、IgA/C3 比值与肾功能指标的相关性。对比不同肾脏病理分级和不同疗效患儿的血清 Gd-IgA1、sFlt-1、IgA/C3 比值。结果：病 例组的 Gd-IgA1、sFlt-1、IgA/C3 比值、BUN、Scr、24hUPE、UP/Scr 均高于对照组 (P<0.05) 。Pearson 相关性分析结果显示：Gd-IgA1、 sFlt-1、IgA/C3 比值与 BUN、Scr、24hUPE、UP/Scr 均呈正相关 (P<0.05) 。随着肾脏病理分级的升高，HSPN 患儿的血清 Gd-IgA1、 sFlt-1、IgA/C3 比值不断升高 (P<0.05) 。无效组的 Gd-IgA1、sFlt-1、IgA/C3 比值高于有效组 (P<0.05) 。结论：Gd-IgA1、sFlt-1、IgA/C3 比值升高参与了 HSPN 患儿的疾病进展，可导致肾损伤，加重肾脏病理改变，临床可根据上述指标变化指导治疗。 [ABSTRACT FROM AUTHOR]

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