Signal-correction errors in the EasyOne Pro LAB multiple-breath washout device significantly impact outcomes in children and adults.
In: Journal of Applied Physiology, Jg. 136 (2024-03-01), Heft 3, S. 460-471
academicJournal
Zugriff:
Multiple-breath washout (MBW) is an established technique to assess functional residual capacity (FRC) and ventilation inhomogeneity in the lung. Indirect calculation of nitrogen concentration requires accurate measurement of gas concentrations. To investigate the accuracy of the CO 2 concentration and molar mass (MM) values used for the indirect calculation of nitrogen concentration in a commercial MBW device [EasyOne Pro LAB (EOPL), ndd Medizintechnik AG, Switzerland] and its impact on outcomes. We used highprecision gas mixtures to evaluate CO 2 and MM sensor output in vivo and in vitro. We developed updated algorithms to correct observed errors and assessed the impact on MBW outcomes and FRC measurement accuracy compared with body plethysmography. The respiratory exchange ratio (RER)-based adjustment of the measured CO 2 signal used in the EOPL led to an overestimated CO 2 signal (range -0.1% to 1.0%). In addition, an uncorrected dependence on humidity was identified. These combined effects resulted in an overestimation of expired nitrogen concentrations (range -0.7% to 2.6%), and consequently MBW outcomes. Corrected algorithms reduced the mean (SD) cumulative expired volume by 15.8% (9.7%), FRC by 6.6% (3.0%), and lung clearance index by 9.9% (7.6%). Differences in FRC between the EOPL and body plethysmography further increased. Inadequate signal correction causes RER- and humidity-dependent expired nitrogen concentration errors and overestimation of test outcomes. Updated algorithms reduce average signal error, however, RER values far from the population average still cause measurement errors. Despite improved signal accuracy, the updated algorithm increased the difference in FRC between the EOPL and body plethysmography. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Applied Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Signal-correction errors in the EasyOne Pro LAB multiple-breath washout device significantly impact outcomes in children and adults.
|
---|---|
Autor/in / Beteiligte Person: | Oestreich, Marc-Alexander ; Wyler, Florian ; Buess, Christian ; Etter, Blaise ; Ramsey, Kathryn A. ; Latzin, Philipp |
Zeitschrift: | Journal of Applied Physiology, Jg. 136 (2024-03-01), Heft 3, S. 460-471 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 8750-7587 (print) |
DOI: | 10.1152/japplphysiol.00096.2022 |
Sonstiges: |
|