مواجهه مزمن مادر با مورفین و ناملایمات اوایل زندگی منجر به اختلال در شکلپذیری سیناپسی موشهای بزرگ آزمایشگاهی نر نوجوان میشود. (Persian)

Introduction: Maternal morphine exposure has negative consequences for learning and memory in the offspring. Maternal Separation (MS) can cause behavioral and neuropsychiatric problems later in life. It seems that adolescents are more susceptible to the effects of early life stress; evidence for the combinatory effects of oral chronic maternal morphine exposure and MS in the CA1 area of the hippocampus in the male adolescent offspring not found. Therefore, this study aimed to evaluate the effects of chronic maternal morphine consumption (21 days before and after mating, and gestation), and MS (180 min/day from postnatal day (PND) 1–21) on the synaptic plasticity of male offspring in mid-adolescence. Methods and Materials: Control, MS, Vehicle (V), Morphine, V+MS, and Morphine+MS groups for in vivo field potential recording from the CA1 area of the hippocampus were tested. Results: The current results demonstrated that chronic maternal morphine exposure impaired the induction of early long-term potentiation (early-LTP). MS impaired average fEPSPs, induction of early-LTP and maintenance. Chronic maternal morphine exposure in combination with MS impaired the induction of early LTP but did not deteriorate maintenance and the average field excitatory postsynaptic potentials (fEPSPs) measured in two hours. Prepulse facilitation ratios remained undisturbed and I/O curves showed decreased fEPSP slopes at high stimulus intensities in combinatory group. Conclusion: We concluded that chronic maternal morphine exposure in combination with MS negatively affects synaptic plasticity in the CA1area in male adolescent offspring. [ABSTRACT FROM AUTHOR]

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