Gene expression of iron transporters, markers of vascularization and structural integrity in placenta of mothers with and without anemia.
In: Molecular Biology Reports, Jg. 51 (2024-05-11), Heft 1, S. 1-7
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Zugriff:
Objective: To compare the mRNA expression of placental iron transporters (TfR-1 and FPN), markers of placental vascularization (VEGF and sFLT1) and marker of structural integrity (LMN-A) in term women with and without iron deficiency anemia. Materials and methods: A total of 30 pregnant women were enrolled; 15 cases of iron deficiency anemia (Hb 7-10.9 gm/dL) and 15 gestational age matched healthy controls (Hb ≥ 11 gm/dL). Peripheral venous blood was collected for assessment of hemoglobin levels and serum iron profile. Placental tissue was used for assessing the mRNA expression of TfR-1, FPN, VEGF, sFLT-1 and LMN-A via real time PCR. Results: Placental expression of TfR-1, VEGF and LMN-A was increased in pregnant women with anemia compared to healthy pregnant controls. Placental expression of sFLT-1 was decreased in pregnant women with anemia compared to healthy pregnant controls. There was no change in the placental expression of FPN. Conclusion: The increased expression of TfR-1, VEGF and LMN-A in cases of iron deficiency anemia are most likely to be compensatory in nature to help maintain adequate fetal iron delivery. What does this study adds to the clinical work: : Compensatory changes in the placenta aimed at buffering transport of iron to the fetus are seen in pregnant women with anemia compared to healthy pregnant controls. [ABSTRACT FROM AUTHOR]
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Titel: |
Gene expression of iron transporters, markers of vascularization and structural integrity in placenta of mothers with and without anemia.
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Autor/in / Beteiligte Person: | Arora, Madhav ; Mehndiratta, Mohit ; Almeida, Edelbert Anthonio ; Kotru, Mrinalini ; Gupta, Bindiya |
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Zeitschrift: | Molecular Biology Reports, Jg. 51 (2024-05-11), Heft 1, S. 1-7 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0301-4851 (print) |
DOI: | 10.1007/s11033-024-09609-z |
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