The Role of Cystine Knots in Collagen Folding and Stability, Part I. Conformational Properties of (Pro-Hyp-Gly)<subscript>5</subscript> and (Pro-(4S)-FPro-Gly)<subscript>5</subscript> Model Trimers with an Artificial Cystine Knot ( For Part II see: D. Barth, O. Kyrieleis, S. Frank, C. Renner, L. Moroder, Chem. Eur J. 2003, 9, 3703–3714, following paper.) Abbreviations: standard abbreviations are used as recommended by the IUPAC-IUB commission on biochemical nomenclature and the ACS Style Guide. All amino acids are of L configuration. Additional abbreviations: CVFF, consistent valence force field; DAST, diethylaminosulfur trifluoride; DBU, 1,8-diazabicyclo[4.4.0]undec-7-ene; DIEA, diisopropylethylamine; DMAP, 4-dimethylaminopyridine; DQF-COSY, double quantum filtered correlation spectroscopy; FPro, 4-fluoroproline; HBTU, N-[(1H-benzotriazol-1-yl)(dimethylamino)met

The Role of Cystine Knots in Collagen Folding and Stability, Part I. Conformational Properties of (Pro-Hyp-Gly)<subscript>5</subscript> and (Pro-(4S)-FPro-Gly)<subscript>5</subscript> Model Trimers with an Artificial Cystine Knot ( For Part II see: D. Barth, O. Kyrieleis, S. Frank, C. Renner, L. Moroder, Chem. Eur J. 2003, 9, 3703–3714, following paper.) Abbreviations: standard abbreviations are used as recommended by the IUPAC-IUB commission on biochemical nomenclature and the ACS Style Guide. All amino acids are of L configuration. Additional abbreviations: CVFF, consistent valence force field; DAST, diethylaminosulfur trifluoride; DBU, 1,8-diazabicyclo[4.4.0]undec-7-ene; DIEA, diisopropylethylamine; DMAP, 4-dimethylaminopyridine; DQF-COSY, double quantum filtered correlation spectroscopy; FPro, 4-fluoroproline; HBTU, N-[(1H-benzotriazol-1-yl)(dimethylamino)met