The impact of IgG antibodies to recombinant Plasmodium falciparum 732 var CIDR-1α domain in mothers and their newborn babies.
In: Parasitology Research, Jg. 101 (2007-08-20), Heft 3, S. 767-774
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Zugriff:
Abstract  Different domains of a novel full-length var gene (termed 732var) isolated from a placenta of a malaria-infected woman were expressed in Escherichia coli as recombinant proteins and analysed biochemically and immunologically. Two of these, the Duffy binding-like (DBL)-3γ domain and the cysteine-rich interdomain region (CIDR)-1α were able to bind chondroitin sulfate A and CD36, respectively. The DBL-3γ domain was investigated in a previous study and confirmed here to exhibit anti-disease characteristics related to pregnancy-associated malaria. Mothers with high anti-DBL-3γ antibody levels were protected from placental infection. The novel finding in this study is that babies born to mothers carrying anti-CIDR-1α antibodies had a delayed time to the first infection. [ABSTRACT FROM AUTHOR]
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The impact of IgG antibodies to recombinant Plasmodium falciparum 732 var CIDR-1α domain in mothers and their newborn babies.
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Autor/in / Beteiligte Person: | Khattab, Ayman ; Chia, Yu-Shan ; May, Jürgen ; Jean-Yves Le Hesran ; Deloron, Philippe ; Klinkert, Mo-Quen |
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Zeitschrift: | Parasitology Research, Jg. 101 (2007-08-20), Heft 3, S. 767-774 |
Veröffentlichung: | 2007 |
Medientyp: | academicJournal |
ISSN: | 0932-0113 (print) |
DOI: | 10.1007/s00436-007-0548-1 |
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