The Effect of Supplementation with Omega-3 Polyunsaturated Fatty Acids on Markers of Oxidative Stress in Elderly Exposed to PM<subscript>2.5</subscript>.
In: Environmental Health Perspectives, Jg. 116 (2008-09-01), Heft 9, S. 1237-1242
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Zugriff:
BACKGROUND: The mechanisms of particulate matter (PM)-induced health effects are believed to involve inflammation and oxidative stress. Increased intake of omega-3 polyunsaturated fatty acids (n-3 PUFA) appears to have anti-inflammatory effects. OBJECTIVE: As part of a trial to evaluate whether n-3 PUFA supplementation could protect against the cardiac alterations linked to PM exposure, we measured biomarkers of response to oxidative stimuli [copper/zinc (Cu/Zn) superoxide dismutase (SOD) activity, lipoperoxidation (LPO) products, and reduced glutathione (GSH)] and evaluated the impact of supplementation on plasma levels. METHODS: We recruited residents from a nursing home in Mexico City chronically exposed to PM ≤ 2.5 µm in aerodynamic diameter (PM 2.5 ) and followed them from 26 September 2001 to 10 April 2002. We randomly assigned subjects in a double-blind fashion to receive either fish oil (n-3 PUFA) or soy oil. We measured PM 2.5 levels indoors at the nursing home, and measured Cu/Zn SOD activity, LPO products, and GSH at different times during presupplementation and supplementation phases. RESULTS: Supplementation with either fish or soy oil was related to an increase of Cu/Zn SOD activity and an increase in GSH plasma levels, whereas exposure to indoor PM 2.5 levels was related to a decrease in Cu/Zn SOD activity and GSH plasma levels. CONCLUSION: Supplementation with n-3 PUFA appeared to modulate the adverse effects of PM 2.5 on these biomarkers, particularly in the fish oil group. Supplementation with n-3 PUFA could modulate oxidative response to PM 2.5 exposure. [ABSTRACT FROM AUTHOR]
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The Effect of Supplementation with Omega-3 Polyunsaturated Fatty Acids on Markers of Oxidative Stress in Elderly Exposed to PM<subscript>2.5</subscript>.
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Autor/in / Beteiligte Person: | Romieu, Isabelle ; Garcia-Esteban, Raquel ; Sunyer, Jordi ; Rios, Camilo ; Alcaraz-Zubeldia, Mireya ; Ruiz Velasco, Silvia ; Holguin, Fernando |
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Zeitschrift: | Environmental Health Perspectives, Jg. 116 (2008-09-01), Heft 9, S. 1237-1242 |
Veröffentlichung: | 2008 |
Medientyp: | academicJournal |
ISSN: | 0091-6765 (print) |
DOI: | 10.1289/ehp.10578 |
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