Efficacy of escitalopram compared to citalopram: a meta-analysis.
In: International Journal of Neuropsychopharmacology, Jg. 14 (2011-03-01), Heft 2, S. 261-268
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Zugriff:
The aim of this review was to assess the clinical relevance of the relative antidepressant efficacy of escitalopram and citalopram by meta-analysis. Studies in major depressive disorder (MDD) with both escitalopram and citalopram treatment arms were identified. Adult patients had to meet DSM-IV criteria for MDD. The primary outcome measure was the treatment difference in Montgomery–Asberg Depression Rating Scale (MADRS) total score at week 8 (or last assessment if <8 wk). Secondary outcome measures were response (⩾50% improvement from baseline) and remission (MADRS ⩽12). A search of the literature and websites found eight randomized controlled trials (RCTs) and onr naturalistic trial, with a total of 2009 patients (escitalopram, n=995; citalopram, n=1014). Escitalopram was significantly more effective than citalopram in overall treatment effect, with an estimated mean treatment difference of 1.7 points at week 8 (or last assessment if <8 wk) on the MADRS (95% CI 0.8–2.6, p=0.0002) (six RCTs used the MADRS), and in responder rate (8.3 percentage points, 95% CI 4.4–12.3) (eight RCTs) and remitter rate (17.6 percentage points, 95% CI 12.1–23.1) analyses (reported for four RCTs), corresponding to number-needed-to-treat (NNT) values of 11.9 (p<0.0001) for response and 5.7 (p<0.0001) for remission. The overall odds ratios were 1.44 (p<0.0003) for response and 1.86 (p<0.0001) for remission, in favour of escitalopram. In this meta-analysis, the statistically significant superior efficacy of escitalopram compared to citalopram was shown to be clinically relevant. [ABSTRACT FROM AUTHOR]
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Titel: |
Efficacy of escitalopram compared to citalopram: a meta-analysis.
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Autor/in / Beteiligte Person: | Montgomery, Stuart ; Hansen, Thomas ; Kasper, Siegfried |
Zeitschrift: | International Journal of Neuropsychopharmacology, Jg. 14 (2011-03-01), Heft 2, S. 261-268 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 1461-1457 (print) |
DOI: | 10.1017/S146114571000115X |
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