Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir.
In: Journal of Antimicrobial Chemotherapy (JAC), Jg. 39 (1997-06-01), Heft 6, S. 821-824
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Zugriff:
A naturally occurring flavone, 5,6,7-trimethoxyflavone (TMF), isolated from the plant Callicarpa japonica, was subjected to antiviral assays. The compound exhibited relatively high inhibitory effects on herpes simplex virus type 1 (HSV-1), human cytomegalovirus and poliovirus. The anti-HSV-1 action was not due to the inhibition of virus adsorption, entry and viral protein synthesis, but might involve, at least in part, a virucidal activity, which results in a suppression of viral binding to host cells at an early replication stage. TMF and acylovir were synergic in their anti-HSV activities at levels below the 50% inhibitory concentrations for antiviral activity. [ABSTRACT FROM AUTHOR]
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Titel: |
Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir.
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Autor/in / Beteiligte Person: | Hayashi, K ; Hayashi, T ; Otsuka, H ; Takeda, Y |
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Zeitschrift: | Journal of Antimicrobial Chemotherapy (JAC), Jg. 39 (1997-06-01), Heft 6, S. 821-824 |
Veröffentlichung: | 1997 |
Medientyp: | academicJournal |
ISSN: | 0305-7453 (print) |
DOI: | 10.1093/jac/39.6.821 |
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