Enhanced coronary vasoconstriction in the Syrian myopathic hamster supports the microvascular spasm hypothesis.
In: Cardiovascular Research, Jg. 28 (1994-03-01), Heft 3, S. 320-324
Online
academicJournal
Zugriff:
Objective: The heart of the young Syrian cardiomyopathic hamster (CMH) displays discrete patches of active myocytolytic necrosis and it has been hypothesised that these lesions are triggered by arteriolar spasm. Accordingly, we tested the theory that the coronary vasoconstrictor response to arginine vasopressin (AVP) infusion is more vigorous in the actively necrotising young (2-3 month old) CMH than in age matched normal hamsters, 5-6 month old CMHs in the histologically quiescent phase of the disease, or 5-6 month old normal hamsters. Methods: An isovolumetric isolated heart preparation was used in which the coronary arteries were perfused with Krebs-Henseleit buffer at constant flow by a syringe pump. Coronary vascular resistance was determined by the ratio of measured perfusion pressure to flow rate during extended diastoles. Results: There were no significant differences in baseline coronary vascular resistance among the four groups. The increase in resistance with AVP infusion (0.54 pressor units·min−1) was significantly greater (p < 0.01) in the young CMH [6.66(SEM 4.75) mm Hg·ml−1·min−1] than in the old CMH [1.66(0.78)], the young normal [1.10(1.07)], and the old normal [2.72(1.86)] groups. Conclusions: There is increased vasoconstrictive responsiveness in the young CMH coronary vasculature. The results suggest a broader coronary abnormality in this myopathic model and are consistent with the microvascular spasm hypothesis of myocytolytic lesion formation.Cardiovascular Research 1994;28:320-324 [ABSTRACT FROM PUBLISHER]
Copyright of Cardiovascular Research is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Enhanced coronary vasoconstriction in the Syrian myopathic hamster supports the microvascular spasm hypothesis.
|
---|---|
Autor/in / Beteiligte Person: | Conway, Robert S ; Natelson, Benjamin H ; Chen, Wen Hwei ; Ting, Windsor |
Link: | |
Zeitschrift: | Cardiovascular Research, Jg. 28 (1994-03-01), Heft 3, S. 320-324 |
Veröffentlichung: | 1994 |
Medientyp: | academicJournal |
ISSN: | 0008-6363 (print) |
Sonstiges: |
|