Syntheses, structures, in vitro cytotoxicities and DNA-binding properties of four copper complexes based on a phenyl 2-pyridyl ketoxime ligand.
In: Transition Metal Chemistry, Jg. 39 (2014-08-01), Heft 5, S. 507-517
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Zugriff:
Four complexes [CuL(µ-O)(dca)] ( 1), [CuL(µ-OH)Cl] ( 2), [CuL(µ-OH)(OAc)]·py ( 3) and [CuL] ( 4) (HL = phenyl 2-pyridyl ketoxime; dca = dicyanamide anion) have been synthesized and characterized by physicochemical and spectroscopic methods. The structures of all three complexes consist of a single or off-set stacked inverse 9-MC-3 metallacrown formed by three L ligands and three Cu atoms, and all of the Cu atoms are located in square planar or square pyramidal geometries with different apical ligands. In complex 4, four L ligands link two Cu atoms to form a dinuclear structure, and the Cu atoms adopt square pyramidal coordination geometry. The in vitro cytotoxicities against four cell lines (A549, HL-60, HT-29 and HCT-116) have been assayed by colorimetric MTT assay. In addition, all four complexes interact strongly with calf thymus DNA, which may be directly responsible for their antitumor activities. [ABSTRACT FROM AUTHOR]
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Titel: |
Syntheses, structures, in vitro cytotoxicities and DNA-binding properties of four copper complexes based on a phenyl 2-pyridyl ketoxime ligand.
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Autor/in / Beteiligte Person: | Li, Ruiling ; Lu, Jing ; Li, Dacheng ; Cheng, Shuang ; Dou, Jianmin |
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Zeitschrift: | Transition Metal Chemistry, Jg. 39 (2014-08-01), Heft 5, S. 507-517 |
Veröffentlichung: | 2014 |
Medientyp: | academicJournal |
ISSN: | 0340-4285 (print) |
DOI: | 10.1007/s11243-014-9826-9 |
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