Volltext verfügbar nach Anmeldung bzw. im Campus-Netz.
Accuracy of Humanitas Ultrasound Criteria in Assessing Disease Activity and Severity in Ulcerative Colitis: A Prospective Study.
In: Journal of Crohn's & Colitis, Jg. 12 (2018-12-01), Heft 12, S. 1385-1391
Online
academicJournal
Zugriff:
Background Colonoscopy [CS] is the standard for assessing disease activity in ulcerative colitis [UC], although invasive and poorly tolerated. Bowel ultrasound [BUS] may be a valid alternative in UC patients; however, the comparative accuracy between BUS and CS is unknown. Methods Consecutive patients with UC were prospectively assessed by CS and BUS. Colonic wall thickening [CWT >3 mm], colonic wall flow at power Doppler [CWF], colonic wall pattern [CWP], and presence of lymph nodes evaluated at BUS were compared with CS. The endoscopic activity was assessed according to the Mayo endoscopic sub-score [0–3]. All BUS investigations were performed by two independent gastroenterologists and the kappa statistic for agreement was calculated. Ultrasonography-based criteria (Humanitas Ultrasound Criteria [HUC]) were developed. Results A total of 53 UC patients [56% with left-sided colitis, 19% with pancolitis] were prospectively enrolled. Of these, 22 patients had mucosal healing [Mayo endoscopic sub-score 0–1] and 31 patients were in endoscopic activity. CWT, CWF, hypoechogenic CWP and the presence of lymph nodes significantly correlated with endoscopic activity [ p < 0.05]. CWT [ p = 0.01] and CWF [ p = 0.09] were independent predictors for endoscopic activity. The HUC developed are: [i] the presence of a CWF and CWT > 3 mm; or [ii] the absence of a CWF and CWT > 4.43 mm. They showed high accuracy for the detection of disease activity [sensitivity 0.71, specificity 1.00]. The interobserver agreement for BUS was excellent [kappa 0.86]. Conclusions BUS is a non-invasive, easy-to-use tool to manage UC patients in clinical practice. HUC were very accurate in assessing disease activity in UC patients. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Crohn's & Colitis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Accuracy of Humanitas Ultrasound Criteria in Assessing Disease Activity and Severity in Ulcerative Colitis: A Prospective Study.
|
---|---|
Autor/in / Beteiligte Person: | Allocca, Mariangela ; Fiorino, Gionata ; Bonovas, Stefanos ; Furfaro, Federica ; Gilardi, Daniela ; Argollo, Marjorie ; Magnoni, Paola ; Peyrin-Biroulet, Laurent ; Danese, Silvio |
Link: | |
Zeitschrift: | Journal of Crohn's & Colitis, Jg. 12 (2018-12-01), Heft 12, S. 1385-1391 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 1873-9946 (print) |
DOI: | 10.1093/ecco-jcc/jjy107 |
Sonstiges: |
|