Bidirectional interaction between oral contraception and lamotrigine in women with epilepsy - Role of progestins.
In: Seizure, Jg. 74 (2020), S. 89-92
Online
academicJournal
Zugriff:
Purpose: To investigate the effects of various progestins in combined oral contraceptives (COCs) on lamotrigine (LTG) serum concentrations and, vice versa, the potential impact of LTG on progestin serum levels during the menstrual cycle. Methods: Twenty women with epilepsy (WWE) undergoing LTG monotherapy and COC (LTG group; mean ± SD [median; range] age 24.2 ± 4.6 [23.0; 18-37] years) as well as fourteen controls on COC (24.9 ± 5.6 [22.5; 20-39] years) were assessed for eligibility and all agreed to participate in the study and remained for data analyses. Results: LTG levels differed significantly between phases of inactive pill and active pill use (p= 0.004), particularly with drospirenon (p= 0.018) and levonorgestrel (p= 0.068) as progestogen component but not with gestoden (p= 0.593). Furthermore, the LTG group showed significantly lower progestin levels during inactive pill when compared to active pill use with respect to levonorgestrel (p= 0.042) and drospirenon (p= 0.018) but not to gestoden (p= 0.109). Progestin concentrations did not differ between patients and controls (p> 0.05). Conclusions: The findings suggest that drospirenon and levonorgestrel but not gestoden seem to reduce LTG serum concentrations when being co-administered in WWE which might be of importance concerning seizure risk. Vice versa, no effect of LTG on several progestins could be demonstrated, arguing against a potential loss of contraception safety with LTG. [ABSTRACT FROM AUTHOR]
Copyright of Seizure is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Bidirectional interaction between oral contraception and lamotrigine in women with epilepsy - Role of progestins.
|
---|---|
Autor/in / Beteiligte Person: | Rauchenzauner, Markus ; Deichmann, Schirin ; Pittschieler, Sabine ; Bergmann, Melanie ; Prieschl, Manuela ; Unterberger, Iris ; Rösing, Benjamin ; Seger, Christoph ; Moser, Christina ; Wildt, Ludwig ; Luef, Gerhard |
Link: | |
Zeitschrift: | Seizure, Jg. 74 (2020), S. 89-92 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1059-1311 (print) |
DOI: | 10.1016/j.seizure.2019.11.011 |
Sonstiges: |
|